A
Ann M. Farese
Researcher at University of Maryland, Baltimore
Publications - 71
Citations - 2359
Ann M. Farese is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Bone marrow & Acute Radiation Syndrome. The author has an hindex of 25, co-authored 71 publications receiving 1945 citations. Previous affiliations of Ann M. Farese include Monsanto.
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Journal ArticleDOI
Filgrastim Improves Survival in Lethally Irradiated Nonhuman Primates
Ann M. Farese,Melanie Cohen,Barry P. Katz,Cassandra P. Smith,Allison Gibbs,Daniel M. Cohen,Thomas J. MacVittie +6 more
TL;DR: Filgrastim, administered at this dose and schedule, effectively mitigated the lethality of the hematopoietic subsyndrome of the acute radiation syndrome.
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Establishing a murine model of the Hematopoietic Syndrome of the Acute Radiation Syndrome
P. Artur Plett,Carol H. Sampson,Hui Lin Chua,Mandar Joshi,Catherine Booth,Alec Gough,Cynthia S. Johnson,Barry P. Katz,Ann M. Farese,Jeffrey Parker,Thomas J. MacVittie,Christie M. Orschell +11 more
TL;DR: Kinetics of loss and recovery of peripheral blood cells in untreated mice and those treated with two MCM, granulocyte-colony stimulating factor and Amifostine further characterized and validated this model for use in screening studies and pivotal efficacy studies of candidate MCM for licensure to treat irradiated individuals suffering from H-ARS.
Journal ArticleDOI
A nonhuman primate model of the hematopoietic acute radiation syndrome plus medical management.
Ann M. Farese,Melanie Cohen,Barry P. Katz,Cassandra P. Smith,William Jackson,Daniel M. Cohen,Thomas J. MacVittie +6 more
TL;DR: A rhesus macaque model of the hematopoietic acute radiation syndrome is established and shows the marked effect of medical management on increased survival and overall mean survival time for decedents following a nuclear terrorist event.
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The prolonged gastrointestinal syndrome in rhesus macaques: the relationship between gastrointestinal, hematopoietic, and delayed multi-organ sequelae following acute, potentially lethal, partial-body irradiation
Thomas J. MacVittie,Alexander Bennett,Catherine Booth,Michael C. Garofalo,Gregory Tudor,Amanda Ward,Terez Shea-Donohue,Daniel Gelfond,Emylee McFarland,William Jackson,Wei Lu,Ann M. Farese +11 more
TL;DR: In this paper, a partial-body irradiation model with 5% bone marrow sparing was established to investigate the prolonged effects of high-dose radiation on the gastrointestinal system, as well as the concomitant hematopoietic syndrome and other multi-organ injury including the lung.
Journal ArticleDOI
Efficient and durable gene marking of hematopoietic progenitor cells in nonhuman primates after nonablative conditioning
Michael Rosenzweig,Thomas J. MacVittie,D. Harper,D Hempel,Rhona L. Glickman,R P Johnson,Ann M. Farese,Narda L. Whiting-Theobald,Gilda F. Linton,G. Yamasaki,Craig T. Jordan,Harry L. Malech +11 more
TL;DR: The data show successful and persistent engraftment of transduced primitive progenitors capable of giving rise to marked cells of multiple hematopoietic lineages, including granulocytes, monocytes, and B and T lymphocytes, in nonhuman primates.