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Narda L. Whiting-Theobald
Researcher at National Institutes of Health
Publications - 25
Citations - 1504
Narda L. Whiting-Theobald is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Genetic enhancement & Severe combined immunodeficiency. The author has an hindex of 16, co-authored 24 publications receiving 1440 citations. Previous affiliations of Narda L. Whiting-Theobald include University of Pennsylvania & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Prolonged production of NADPH oxidase-corrected granulocytes after gene therapy of chronic granulomatous disease
Harry L. Malech,Phillip B. Maples,Narda L. Whiting-Theobald,Gilda F. Linton,Sudhir Sekhsaria,Sarah J. Vowells,Fei Li,Judi A. Miller,Ellen S. DeCarlo,Steven M. Holland,Susan F. Leitman,Charles S. Carter,Robert E. Butz,Elizabeth J. Read,Thomas A. Fleisher,Richard Schneiderman,Dennis E. Van Epps,S. Kaye Spratt,Christopher A. Maack,Joseph Rokovich,Lawrence K. Cohen,John I. Gallin +21 more
TL;DR: This trial piloted the use of animal protein-free medium and a blood-bank-compatible closed system of gas-permeable plastic containers for culture and transduction of the PBSCs and found that these features enhance the safety of PBSCs directed gene therapy.
Journal ArticleDOI
CXCR4‐Transgene Expression Significantly Improves Marrow Engraftment of Cultured Hematopoietic Stem Cells
Sebastian Brenner,Narda L. Whiting-Theobald,Toshinao Kawai,Toshinao Kawai,Gilda F. Linton,Andrew G. Rudikoff,Uimook Choi,Martin F. Ryser,Philip M. Murphy,Joan M.G. Sechler,Harry L. Malech +10 more
TL;DR: It is concluded that transduction‐mediated overexpression of CXCR4 significantly improves marrow engraftment of cultured PBSCs and contributes to marrow reconstitution potential during ex vivo culture.
Journal ArticleDOI
Hypomorphic Rag mutations can cause destructive midline granulomatous disease.
Suk See De Ravin,Edward W. Cowen,Kol A. Zarember,Narda L. Whiting-Theobald,Douglas B. Kuhns,Netanya G. Sandler,Daniel C. Douek,Stefania Pittaluga,Pietro Luigi Poliani,Yu Nee Lee,Luigi D. Notarangelo,Lei Wang,Frederick W. Alt,Elizabeth M. Kang,Joshua D. Milner,Julie E. Niemela,Mary Fontana-Penn,Sara H. Sinal,Harry L. Malech +18 more
TL;DR: An adolescent patient with myasthenia gravis treated with thymectomy subsequently developed extensive granulomatous destruction of midface structures, palate, nasal septum, airways, and epiglottis, and his thymus was dysplastic and, although not depleted of T cells, showed a notable absence of autoimmune regulator and Foxp3(+) regulatory T cells.
Journal ArticleDOI
Efficient and durable gene marking of hematopoietic progenitor cells in nonhuman primates after nonablative conditioning
Michael Rosenzweig,Thomas J. MacVittie,D. Harper,D Hempel,Rhona L. Glickman,R P Johnson,Ann M. Farese,Narda L. Whiting-Theobald,Gilda F. Linton,G. Yamasaki,Craig T. Jordan,Harry L. Malech +11 more
TL;DR: The data show successful and persistent engraftment of transduced primitive progenitors capable of giving rise to marked cells of multiple hematopoietic lineages, including granulocytes, monocytes, and B and T lymphocytes, in nonhuman primates.
Journal ArticleDOI
Gene therapy improves immune function in preadolescents with X-linked severe combined immunodeficiency
Javier Chinen,Joie Davis,Suk See De Ravin,Beverly N. Hay,Amy P. Hsu,Gilda F. Linton,Nora Naumann,Effie Y.H. Nomicos,Christopher Silvin,Jean Ulrick,Narda L. Whiting-Theobald,Harry L. Malech,Jennifer M. Puck +12 more
TL;DR: Retroviral gene therapy can restore immunity to infants with X-linked severe combined immunodeficiency (XSCID) caused by mutations in the IL2RG gene encoding the common gamma chain of receptors for interleukins 2 (IL-2).