A
Anna Aspesi
Researcher at Health Science University
Publications - 47
Citations - 1760
Anna Aspesi is an academic researcher from Health Science University. The author has contributed to research in topics: Diamond–Blackfan anemia & Ribosomal protein. The author has an hindex of 21, co-authored 43 publications receiving 1413 citations. Previous affiliations of Anna Aspesi include University of Eastern Piedmont & University of Turin.
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Journal ArticleDOI
The ribosomal basis of Diamond-Blackfan Anemia: mutation and database update.
Ilenia Boria,Emanuela Garelli,Hanna T. Gazda,Hanna T. Gazda,Anna Aspesi,Paola Quarello,Elisa Pavesi,Daniela Ferrante,Joerg J Meerpohl,Mutlu Kartal,Lydie Da Costa,Lydie Da Costa,Alexis Proust,Thierry Leblanc,Maud Simansour,Niklas Dahl,Anne-Sophie Fröjmark,Dagmar Pospisilova,Radek Cmejla,Alan H. Beggs,Alan H. Beggs,Mee Rie Sheen,Michael Landowski,Christopher Buros,Catherine Clinton,Lori J. Dobson,Adrianna Vlachos,Adrianna Vlachos,Eva Atsidaftos,Eva Atsidaftos,Jeffrey M. Lipton,Jeffrey M. Lipton,Steven R. Ellis,Ugo Ramenghi,Irma Dianzani +34 more
TL;DR: Experimental evidence supports the hypothesis that DBA is primarily the result of defective ribosome synthesis, and bioinformatic tools show that gene conversion mechanism is not common in RP genes mutagenesis, notwithstanding the abundance of RP pseudogenes.
Journal ArticleDOI
Human RPS19, the gene mutated in Diamond-Blackfan anemia, encodes a ribosomal protein required for the maturation of 40S ribosomal subunits
Johan Flygare,Anna Aspesi,Anna Aspesi,Joshua Cory Bailey,Koichi Miyake,Koichi Miyake,Jacqueline Marie Caffrey,Stefan Karlsson,Steven R. Ellis +8 more
TL;DR: Analysis of intermediates in CD34- cells from the bone marrow of patients with DBA harboring mutations in RPS19 revealed a pre-rRNA-processing defect similar to that observed in TF-1 cells where RPS21 expression was reduced, which can be monitored by studying rRNA- processing intermediates along the ribosome synthesis pathway.
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Osteopontin at the Crossroads of Inflammation and Tumor Progression.
Luigi Mario Castello,Davide Raineri,Livia Salmi,Nausicaa Clemente,Rosanna Vaschetto,Marco Quaglia,Massimiliano Garzaro,Sergio Gentilli,Paolo Navalesi,Vincenzo Cantaluppi,Umberto Dianzani,Anna Aspesi,Annalisa Chiocchetti +12 more
TL;DR: The role of systemic, tumor-derived, and stroma-derived OPN is described, highlighting its pivotal role at the crossroads of inflammation and tumor progression, and its heterogeneous functions according to the cell type and tumor microenvironment.
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Diamond-Blackfan anemia: genotype-phenotype correlations in Italian patients with RPL5 and RPL11 mutations.
Paola Quarello,Emanuela Garelli,Adriana Carando,Alfredo Brusco,Roberto Calabrese,Carlo Dufour,Daniela Longoni,Aldo Misuraca,Luciana Vinti,Anna Aspesi,Laura Biondini,Fabrizio Loreni,Irma Dianzani,Ugo Ramenghi +13 more
TL;DR: Genotype-phenotype data suggest that mutation screening should begin with RPL5 and RPL11 in patients with Diamond-Blackfan anemia with malformations, and a close association was evident between RPL 5 mutations and craniofacial malformation, and between hand malformATIONS and R PL11 mutations.
Journal ArticleDOI
Rare ribosomopathies: insights into mechanisms of cancer.
Anna Aspesi,Steven R. Ellis +1 more
TL;DR: The goal here is to compare and contrast the pathophysiological mechanisms underpinning ribosomopathies to gain a better understanding of the mechanisms that predispose these disorders to cancer.