Anna Maria Orengo

TL;DR: Support to the concept that p58 molecules represent a NK receptor delivering a negative signal was provided by experiments in which the entire anti-p58 mAbs could inhibit the lysis of unprotected Fc gamma R- target cells, thus mimicking the inhibitory effect of MHC class I molecules.

TL;DR: Peptide map analysis indicated that EB6 (or GL183) molecules precipitated from double-positive clones were identical to the corresponding molecules isolated from single-positive ones, thus indicating that the two antigenic determinants are carried by two distinct molecules.

TL;DR: It appears that CD69 molecules may initiate a pathway of activation of cytolytic functions common to a number of activated effector lymphocytes with the remarkable exception of TCR alpha/beta+ cy tolytic cells.

TL;DR: It is inferred that Cw3 expression on (both human and murine) target cells confers selective protection from lysis mediated by anti-2 NK clones, which could represent the element conferring selective resistance to lysis byAnti-2 clones.

TL;DR: The comparative analysis of the segregation of the major histocompatibility complex haplotypes and the recessive or dominant alleles of the genes governing the five specificities analyzed indicated that there is no independent sampling between the two genetic traits, thus suggesting that the genes regulating the NK-defined specificities are carried by chromosome 6.