E
Ermanno Ciccone
Researcher at University of Genoa
Publications - 92
Citations - 5524
Ermanno Ciccone is an academic researcher from University of Genoa. The author has contributed to research in topics: T-cell receptor & Antigen. The author has an hindex of 39, co-authored 92 publications receiving 5380 citations. Previous affiliations of Ermanno Ciccone include Ludwig Institute for Cancer Research & University of Turin.
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Journal ArticleDOI
P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities.
Alessandro Moretta,Massimo Vitale,Cristina Bottino,Anna Maria Orengo,Luigia Morelli,Raffaella Augugliaro,M Barbaresi,Ermanno Ciccone,Lorenzo Moretta +8 more
TL;DR: Support to the concept that p58 molecules represent a NK receptor delivering a negative signal was provided by experiments in which the entire anti-p58 mAbs could inhibit the lysis of unprotected Fc gamma R- target cells, thus mimicking the inhibitory effect of MHC class I molecules.
Journal ArticleDOI
Identification of four subsets of human CD3-CD16+ natural killer (NK) cells by the expression of clonally distributed functional surface molecules: correlation between subset assignment of NK clones and ability to mediate specific alloantigen recognition.
Alessandro Moretta,Cristina Bottino,Daniela Pende,Gino Tripodi,Giuseppe Tambussi,O Viale,Anna Maria Orengo,M Barbaresi,Annalisa Merli,Ermanno Ciccone +9 more
TL;DR: Peptide map analysis indicated that EB6 (or GL183) molecules precipitated from double-positive clones were identical to the corresponding molecules isolated from single-positive ones, thus indicating that the two antigenic determinants are carried by two distinct molecules.
Journal ArticleDOI
Peptide Specificity in the Recognition of MHC Class I by Natural Killer Cell Clones
Mauro S. Malnati,Marta Peruzzi,Kenneth C. Parker,William E. Biddison,Ermanno Ciccone,Alessandro Moretta,Eric O. Long +6 more
TL;DR: It is shown that specific self peptides, complexed with MHC class I, provide protection from NK-mediated lysis, and that recognition was peptide-specific.
Journal ArticleDOI
A novel surface antigen expressed by a subset of human CD3- CD16+ natural killer cells. Role in cell activation and regulation of cytolytic function.
Alessandro Moretta,Giuseppe Tambussi,Cristina Bottino,Gino Tripodi,Annalisa Merli,Ermanno Ciccone,Giuseppe Pantaleo,Lorenzo Moretta +7 more
TL;DR: Analysis of GL183+ or GL183- NK clones for their ability to lyse human (IGROV I) or murine tumor target cells indicated thatGL183- clones were, on average, fivefold more efficient in inducing target cell lysis.
Book ChapterDOI
Human Natural Killer Cells: Origin, Clonality, Specificity, and Receptors
TL;DR: The ability of activated NK cells to lyse efficiently a wider spectrum of tumor cells can be interpreted as the expression of appropriate activation receptors on these cells as a consequence of cell activation.