A
Anna Richardson
Researcher at University of Oxford
Publications - 10
Citations - 543
Anna Richardson is an academic researcher from University of Oxford. The author has contributed to research in topics: Haplotype & Malaria. The author has an hindex of 9, co-authored 10 publications receiving 519 citations. Previous affiliations of Anna Richardson include John Radcliffe Hospital & Wellcome Trust.
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Journal ArticleDOI
Functional consequences of a polymorphism affecting NF-kappaB p50-p50 binding to the TNF promoter region.
Irina A. Udalova,Anna Richardson,Agnes Denys,Clive Smith,Hans Ackerman,Brian M. J. Foxwell,Dominic P. Kwiatkowski +6 more
TL;DR: Using an adenoviral reporter assay, the variant which binds p50-p50 results in a reduction of lipopolysaccharide-inducible gene expression in primary human monocytes and illustrates the potential for genetic modulation of inflammatory gene regulation in humans by subtle nucleotide changes that alter the relative binding affinities of different forms of the NF-κB complex.
Journal ArticleDOI
Haplotypic analysis of the TNF locus by association efficiency and entropy
Hans Ackerman,Stanley Usen,Richard Mott,Anna Richardson,Anna Richardson,Fatoumatta Sisay-Joof,Pauline Katundu,Terrie E. Taylor,Ryk Ward,Malcolm E. Molyneux,Margaret Pinder,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski +12 more
TL;DR: The TNF locus in the Gambian and Malawi sample is haplotypically diverse and has a rich history of intragenic recombination, and a large proportion of TNF SNPs must be typed to detect a disease-modifying SNP at this locus.
Journal ArticleDOI
Lack of association of interferon regulatory factor 1 with severe malaria in affected child-parental trio studies across three african populations
Valentina D. Mangano,Taane G. Clark,Sarah Auburn,Susana Campino,Mahamadou Diakite,Andrew E. Fry,Angela Green,Anna Richardson,Muminatou Jallow,Fatou Sisay-Joof,Margaret Pinder,Michael J. Griffiths,Charles R. Newton,Norbert Peshu,Thomas N. Williams,Kevin Marsh,Malcolm E. Molyneux,Terrie E. Taylor,David Modiano,Dominic P. Kwiatkowski,Kirk A. Rockett +20 more
TL;DR: The results offer no evidence that the molecular pathways regulated by the transcription factor IRF-1 are involved in the immune-based pathogenesis of severe malaria.
Journal ArticleDOI
Tumor necrosis factor and lymphotoxin-α polymorphisms and severe malaria in African populations
Taane G. Clark,Mahamadou Diakite,Sarah Auburn,Susana Campino,Andrew E. Fry,Angela Green,Anna Richardson,Kerrin S. Small,Yik Y. Teo,Jonathan Wilson,Muminatou Jallow,Fatou Sisay-Joof,Margaret Pinder,Michael J. Griffiths,Norbert Peshu,Thomas N. Williams,Thomas N. Williams,Kevin Marsh,Malcolm E. Molyneux,Malcolm E. Molyneux,Terrie E. Taylor,Terrie E. Taylor,Kirk A. Rockett,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski +24 more
TL;DR: Evidence is found to support the reported associations between the TNF -238 polymorphism and SM in The Gambia, but no TNF/LTA polymorphisms were found to be associated with SM in cohorts in Kenya and Malawi.
Journal ArticleDOI
TLR9 polymorphisms in African populations: no association with severe malaria, but evidence of cis-variants acting on gene expression
Susana Campino,Julian Forton,Sarah Auburn,Sarah Auburn,Andrew E. Fry,Mahamadou Diakite,Anna Richardson,Jeremy Hull,Muminatou Jallow,Fatou Sisay-Joof,Margaret Pinder,Malcolm E. Molyneux,Terrie E. Taylor,Kirk A. Rockett,Taane G. Clark,Taane G. Clark,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski +17 more
TL;DR: Using the largest cohorts analysed to date, as well as a standardized phenotype definition and study design, no association of TLR9 genetic variants with severe malaria was found and it remains possible that there are rare variants with association signals.