Maria Peiris-Pagès

TL;DR: How cancer cells reprogramme their metabolism and that of other cells within the tumour microenvironment in order to survive and propagate, thus driving disease progression is discussed; in particular, potential metabolic vulnerabilities that might be targeted therapeutically are highlighted.

TL;DR: Owing to a typesetting error, the final line of text in Box 3, and the abbreviation lists for Tables 2 and 3 were omitted from the print and the online pdf versions of this article; for Table 3, the abbrevation list was also omitted fromThe online html version.

TL;DR: Determining the role of cancer stem cell metabolism in carcinogenesis has become a major focus in cancer research, and substantial efforts are conducted towards discovering clinical targets.

TL;DR: It is shown that new mitochondrial biogenesis is required for the anchorage independent survival and propagation of cancer stem-like cells (CSCs) and that doxycycline could be re-purposed clinically as a ‘safe’ mitochondrial inhibitor, to target FOXM1 and mitochondrialBiogenesis in CSCs, to prevent tumor recurrence and distant metastasis, thereby avoiding patient relapse.

TL;DR: Graphene oxide is shown to be an effective non-toxic therapeutic strategy for the eradication of cancer stem cells, via differentiation-based nano-therapy and Mechanistically, it is presented evidence that GO exerts its striking effects on CSCs by inhibiting several key signal transduction pathways and thereby inducing CSC differentiation.