Vincenzo Pezzi

TL;DR: It is discovered that 17β-estradiol (E2), and the two major phytoestrogens, genistein and quercetin, stimulate c-fos expression through ERα as well as through an ER-independent manner via the G protein-coupled receptor homologue GPR30.

TL;DR: The current knowledge concerning the role of estrogen/estrogen receptors molecular pathways in regulating GnRH, follicle-stimulating hormone, and luteinizing hormone release at the hypothalamic and pituitary levels in males as well as in controlling specific testicular functions such as spermatogenesis is summarized.

TL;DR: It is shown that new mitochondrial biogenesis is required for the anchorage independent survival and propagation of cancer stem-like cells (CSCs) and that doxycycline could be re-purposed clinically as a ‘safe’ mitochondrial inhibitor, to target FOXM1 and mitochondrialBiogenesis in CSCs, to prevent tumor recurrence and distant metastasis, thereby avoiding patient relapse.

TL;DR: The strategies used to improve pharmacokinetic characteristics and then beneficial effects of RSV are described and the biological results obtained on several synthetic derivatives containing different substituents, such as methoxylic, hydroxylic groups, or halogens on the RSV aromatic rings, will be described.

TL;DR: Results indicate for the first time that estrogens, through a cross talk between GPR30 and ERalpha, activate the rapid EGFR/ERK/fos pathway, which in turn stimulate mouse GC-1 cell proliferation.