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Angela Goncalves
Researcher at Wellcome Trust Sanger Institute
Publications - 25
Citations - 3486
Angela Goncalves is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Gene & Induced pluripotent stem cell. The author has an hindex of 13, co-authored 24 publications receiving 2502 citations. Previous affiliations of Angela Goncalves include Oklahoma State Department of Health & European Bioinformatics Institute.
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Journal ArticleDOI
Single-cell reconstruction of the early maternal–fetal interface in humans
Roser Vento-Tormo,Roser Vento-Tormo,Mirjana Efremova,Rachel A. Botting,Margherita Y. Turco,Miquel Vento-Tormo,Kerstin B. Meyer,Jong-Eun Park,Emily Stephenson,Krzysztof Polanski,Angela Goncalves,Angela Goncalves,Lucy Gardner,Staffan Holmqvist,Johan Henriksson,Angela Zou,Andrew M. Sharkey,Ben Millar,Barbara A. Innes,Laura Wood,Anna Wilbrey-Clark,Rebecca Payne,Martin A. Ivarsson,Steve Lisgo,Andrew Filby,David H. Rowitch,Judith N. Bulmer,Gavin J. Wright,Michael J. T. Stubbington,Muzlifah Haniffa,Muzlifah Haniffa,Ashley Moffett,Sarah A. Teichmann,Sarah A. Teichmann,Sarah A. Teichmann +34 more
TL;DR: A single-cell atlas of the maternal–fetal interface reveals the cellular organization of the decidua and placenta, and the interactions that are critical for placentation and reproductive success, and develops a repository of ligand–receptor complexes and a statistical tool to predict the cell–cell communication via these molecular interactions.
Journal ArticleDOI
Common genetic variation drives molecular heterogeneity in human iPSCs
Helena Kilpinen,Angela Goncalves,Andreas Leha,Vackar Afzal,Kaur Alasoo,Sofie Ashford,Sendu Bala,Dalila Bensaddek,Francesco Paolo Casale,Oliver J. Culley,Petr Danacek,Adam Faulconbridge,Peter W. Harrison,Annie Kathuria,Davis J. McCarthy,Davis J. McCarthy,Shane A. McCarthy,Ruta Meleckyte,Yasin Memari,Nathalie Moens,Filipa A.C. Soares,Alice L. Mann,Ian Streeter,Chukwuma A. Agu,Alex Alderton,Rachel Nelson,Sarah Harper,Minal Patel,A. White,Sharad R. Patel,Laura Clarke,Reena Halai,Christopher M. Kirton,Anja Kolb-Kokocinski,Philip L. Beales,Ewan Birney,Davide Danovi,Angus I. Lamond,Willem H. Ouwehand,Willem H. Ouwehand,Willem H. Ouwehand,Ludovic Vallier,Ludovic Vallier,Fiona M. Watt,Richard Durbin,Oliver Stegle,Daniel J. Gaffney +46 more
TL;DR: This study outlines the major sources of genetic and phenotypic variation in iPS cells and establishes their suitability as models of complex human traits and cancer.
Journal ArticleDOI
A global map of human gene expression
Margus Lukk,Misha Kapushesky,Janne Nikkilä,Helen Parkinson,Angela Goncalves,Wolfgang Huber,Esko Ukkonen,Alvis Brazma +7 more
TL;DR: A global gene expression map is constructed by integrating microarray data from 5,372 human samples representing 369 different cell and tissue types, disease states and cell lines and reveals that it can be described by a small number of distinct expression profile classes.
Journal ArticleDOI
Rapid Turnover of Long Noncoding RNAs and the Evolution of Gene Expression
Claudia Kutter,Stephen Watt,Klara Stefflova,Michael D. Wilson,Angela Goncalves,Angela Goncalves,Chris P. Ponting,Chris P. Ponting,Duncan T. Odom,Duncan T. Odom,Ana C. Marques +10 more
TL;DR: The findings show that nearly half of intergenic lncRNA loci have been gained or lost since the last common ancestor of mouse and rat, and they predict that such rapid transcriptional turnover contributes to the evolution of tissue- and lineage-specific gene expression.
Journal ArticleDOI
Effects of nanoplastics on Mytilus galloprovincialis after individual and combined exposure with carbamazepine.
I. Brandts,Mariana Teles,Angela Goncalves,A. Barreto,Lorena Franco-Martínez,Asta Tvarijonaviciute,Manuel A. Martins,Amadeu M.V.M. Soares,Lluis Tort,Miguel Oliveira +9 more
TL;DR: It is demonstrated that PS, even at low concentrations, led to alterations on the assessed mussels' endpoints, showing that nanoplastics can induce oxidative damage.