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Anne Beauvais
Researcher at Pasteur Institute
Publications - 83
Citations - 5360
Anne Beauvais is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Aspergillus fumigatus & Cell wall. The author has an hindex of 41, co-authored 83 publications receiving 4590 citations.
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Journal ArticleDOI
FLO1 Is a Variable Green Beard Gene that Drives Biofilm-like Cooperation in Budding Yeast
Scott Smukalla,Marina Caldara,Nathalie Pochet,Nathalie Pochet,Anne Beauvais,Stéphanie Guadagnini,Chen Yan,Marcelo D. Vinces,An Jansen,An Jansen,Marie Christine Prevost,Jean-Paul Latgé,Gerald R. Fink,Kevin R. Foster,Kevin J. Verstrepen,Kevin J. Verstrepen,Kevin J. Verstrepen +16 more
TL;DR: This work shows that S. cerevisiae is also a model for the evolution of cooperative behavior by revisiting flocculation, a self-adherence phenotype lacking in most laboratory strains, and expresses the gene FLO1, which is driven by one of a few known "green beard genes," which direct cooperation toward other carriers of the same gene.
Journal ArticleDOI
An extracellular matrix glues together the aerial-grown hyphae of Aspergillus fumigatus.
Anne Beauvais,Christine Schmidt,Stéphanie Guadagnini,Pascal Roux,Emmanuelle Perret,Christine Henry,Sophie Paris,Adeline Mallet,Marie-Christine Prévost,Jean-Paul Latgé +9 more
TL;DR: This is the first analysis of the three dimensional structure of a mycelial colony, and knowledge of this multicellular organization will impact the future understanding of the pathobiology of aerial mold pathogens.
Journal ArticleDOI
Aspergillus galactosaminogalactan mediates adherence to host constituents and conceals hyphal β-glucan from the immune system.
Fabrice N. Gravelat,Anne Beauvais,Hong Liu,Mark J. Lee,Brendan D. Snarr,Dan Chen,Wenjie Xu,Ilia Kravtsov,Christopher M.-Q. Hoareau,Ghyslaine Vanier,Mirjam Urb,Paolo Campoli,Qusai Al Abdallah,Melanie Lehoux,Josée C. Chabot,Marie-Claude Ouimet,Stefanie D. Baptista,Jörg H. Fritz,William C. Nierman,Jean-Paul Latgé,Aaron P. Mitchell,Scott G. Filler,Scott G. Filler,Thierry Fontaine,Donald C. Sheppard +24 more
TL;DR: A role is established for galactosaminogalactan as a pivotal bifunctional virulence factor in the pathogenesis of invasive aspergillosis using mutants with different adhesive properties and comparative transcriptomics to discover the gene uge3, encoding a fungal epimerase, is required for adherence.
Journal ArticleDOI
In vivo biofilm composition of Aspergillus fumigatus.
Céline Loussert,Christine Schmitt,Marie-Christine Prévost,Viviane Balloy,Elie Fadel,Bruno Philippe,Catherine Kauffmann-Lacroix,Jean-Paul Latgé,Anne Beauvais +8 more
TL;DR: The in vivo composition of the mycelial extracellular matrix of Aspergillus fumigatus during host invasion is reported here for the first time and a new galactosaminogalactan and the galactomannan were the major polysaccharides of the in vivo ECM.
Journal ArticleDOI
Aspergillus Cell Wall Melanin Blocks LC3-Associated Phagocytosis to Promote Pathogenicity
Tonia Akoumianaki,Irene Kyrmizi,Isabel Valsecchi,Mark S. Gresnigt,Mark S. Gresnigt,George Samonis,Elias Drakos,Dimitrios T. Boumpas,Laetitia Muszkieta,Marie Christine Prevost,Marie Christine Prevost,Dimitrios P. Kontoyiannis,Triantafyllos Chavakis,Mihai G. Netea,Mihai G. Netea,Frank L. van de Veerdonk,Frank L. van de Veerdonk,Axel A. Brakhage,Jamel El-Benna,Jamel El-Benna,Anne Beauvais,Jean-Paul Latgé,Georgios Chamilos +22 more
TL;DR: Two events that occur concomitantly during germination of airborne fungi, surface exposure of PAMPs and melanin removal, are necessary for LAP activation and fungal killing.