Anne-Catherine Heuskin

TL;DR: This roadmap outlines the potential roles of metallic nanoparticles in the field of radiation therapy and covers contributions from experts in these topics summarizing their view of the current status and challenges, as well as expected advancements in technology to address these challenges.

TL;DR: The current state of knowledge is reviewed by addressing how gold nanoparticles exert their radiosensitizing effects from a transdisciplinary perspective and the current and future challenges to go towards a successful clinical translation of this promising therapeutic approach.

TL;DR: Interestingly, when investigating the influence of UV‐A and UV‐B exposure on the genomic integrity of desiccated bdelloids, it was observed that these natural radiations also caused important DNA DSBs, suggesting that the genome is not protected during the desiccation stage but that the repair mechanisms are extremely efficient in these intriguing organisms.

TL;DR: A major role of reactive oxygen species in the amplification of the death of irradiated cell was identified and novel perspectives for using high-Z metallic NPs in protontherapy are opened up.

TL;DR: It is shown that M1 macrophages (THP-1 cell line) were more resistant to proton irradiation than unpolarized (M0) and M2macrophages, which correlated with differential DNA damage detection, and propton irradiation-induced macrophage reprogramming from M2 to a mixed M1/M2 phenotype is suggested.