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Anne Dubart-Kupperschmitt
Researcher at French Institute of Health and Medical Research
Publications - 59
Citations - 2689
Anne Dubart-Kupperschmitt is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Induced pluripotent stem cell & Stem cell. The author has an hindex of 23, co-authored 56 publications receiving 2444 citations. Previous affiliations of Anne Dubart-Kupperschmitt include Centre national de la recherche scientifique & University of Paris.
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Ex vivo expansion of human hematopoietic stem cells by direct delivery of the HOXB4 homeoprotein.
Sophie Amsellem,Françoise Pflumio,Dominique Bardinet,Brigitte Izac,Pierre Charneau,Paul-Henri Romeo,Anne Dubart-Kupperschmitt,Serge Fichelson +7 more
TL;DR: This method provides a basis for developing cell therapy strategies using expanded HSCs that are not genetically modified and takes advantage of the ability of HOX proteins to passively translocate through cell membranes to eliminate any deleterious effects.
Journal ArticleDOI
The human immunodeficiency virus type-1 central DNA flap is a crucial determinant for lentiviral vector nuclear import and gene transduction of human hematopoietic stem cells.
Aude Sirven,Françoise Pflumio,Véronique Zennou,Monique Titeux,William Vainchenker,Laure Coulombel,Anne Dubart-Kupperschmitt,Pierre Charneau +7 more
TL;DR: The reinsertion of the DNA flap sequence in an HIV-derived lentiviral vector promotes a striking increase of gene transduction efficiency in human CD34+ hematopoietic cells, and the complementation of the nuclear import defect present in the parental vector accounts for this result.
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FOXO1 regulates L-Selectin and a network of human T cell homing molecules downstream of phosphatidylinositol 3-kinase.
Stéphanie Fabre,Florent Carrette,Florent Carrette,Jing Chen,Valérie Lang,Monique Semichon,Monique Semichon,Christine Denoyelle,Christine Denoyelle,Vladimir Lazar,Nicolas Cagnard,Nicolas Cagnard,Anne Dubart-Kupperschmitt,Anne Dubart-Kupperschmitt,Marianne Mangeney,Marianne Mangeney,David A. Fruman,Georges Bismuth,Georges Bismuth +18 more
TL;DR: It is reported that FOXO1 controls the expression of L-selectin, an essential homing molecule, in human T lymphocytes, and it is suggested that PI3K controls a coordinated network of transcription factors regulating both cell quiescence and homing of humanT lymphocytes.
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Generation of functional cholangiocyte-like cells from human pluripotent stem cells and HepaRG cells
Noushin Dianat,Hélène Dubois-Pot-Schneider,Clara Steichen,Christophe Desterke,Philippe Leclerc,Aurélien Raveux,Laurent Combettes,Anne Weber,Anne Corlu,Anne Dubart-Kupperschmitt +9 more
TL;DR: A robust and efficient method for differentiating pluripotent stem cells into cholangiocyte‐like cells, which display structural and functional similarities to bile duct cells in normal liver, is developed.
Journal ArticleDOI
Enhanced transgene expression in cord blood CD34(+)-derived hematopoietic cells, including developing T cells and NOD/SCID mouse repopulating cells, following transduction with modified trip lentiviral vectors
Aude Sirven,Emmanuel Ravet,Pierre Charneau,Véronique Zennou,Laure Coulombel,Denise Guetard,Françoise Pflumio,Anne Dubart-Kupperschmitt +7 more
TL;DR: An HIV-derived lentiviral vector is presented, TRIPDeltaU3-EF1alpha, which can very efficiently transduce human cord blood HSC and results in high long-term transgene expression in CD34(+)-derived T, B, NK, and myeloid hematopoietic cells.