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Anne J. Novak
Researcher at Mayo Clinic
Publications - 190
Citations - 10169
Anne J. Novak is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Follicular lymphoma & Diffuse large B-cell lymphoma. The author has an hindex of 46, co-authored 165 publications receiving 8621 citations. Previous affiliations of Anne J. Novak include University of Texas MD Anderson Cancer Center & ZymoGenetics.
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Journal ArticleDOI
Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes
Bjoern Chapuy,Chip Stewart,Andrew Dunford,Jaegil Kim,Atanas Kamburov,Robert A. Redd,Michael S. Lawrence,Michael S. Lawrence,Margaretha G.M. Roemer,Amy Li,Marita Ziepert,Annette M. Staiger,Annette M. Staiger,Jeremiah Wala,Matthew D. Ducar,Ignaty Leshchiner,Ester Rheinbay,Amaro Taylor-Weiner,Caroline A. Coughlin,Julian M. Hess,Chandra Sekhar Pedamallu,Dimitri Livitz,Daniel Rosebrock,Mara Rosenberg,Adam Tracy,Heike Horn,Paul Van Hummelen,Andrew L. Feldman,Brian K. Link,Anne J. Novak,James R. Cerhan,Thomas M. Habermann,Reiner Siebert,Andreas Rosenwald,Aaron R. Thorner,Matthew Meyerson,Matthew Meyerson,Todd R. Golub,Todd R. Golub,Rameen Beroukhim,Rameen Beroukhim,Gerald Wulf,German Ott,Scott J. Rodig,Scott J. Rodig,Stefano Monti,Donna Neuberg,Markus Loeffler,Michael Pfreundschuh,Lorenz Trümper,Gad Getz,Gad Getz,Margaret A. Shipp +52 more
TL;DR: A comprehensive genetic analysis of 304 primary DLBCLs identified low-frequency alterations, captured recurrent mutations, somatic copy number alterations, and structural variants, and defined coordinate signatures in patients with available outcome data to provide a roadmap for an actionableDLBCL classification.
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Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing
Jens G. Lohr,Petar Stojanov,Petar Stojanov,Michael S. Lawrence,Daniel Auclair,Bjoern Chapuy,Carrie Sougnez,Peter Cruz-Gordillo,Birgit Knoechel,Birgit Knoechel,Yan W. Asmann,Susan L. Slager,Anne J. Novak,Ahmet Dogan,Stephen M. Ansell,Brian K. Link,Lihua Zou,Joshua Gould,Gordon Saksena,Nicolas Stransky,Claudia Rangel-Escareño,Juan Carlos Fernández-López,Alfredo Hidalgo-Miranda,Jorge Melendez-Zajgla,Enrique Hernández-Lemus,Angela Schwarz-Cruz y Celis,Ivan Imaz-Rosshandler,Akinyemi I. Ojesina,Joonil Jung,Chandra Sekhar Pedamallu,Eric S. Lander,Eric S. Lander,Eric S. Lander,Thomas M. Habermann,James R. Cerhan,Margaret A. Shipp,Gad Getz,Todd R. Golub +37 more
TL;DR: It is shown that BCL2 mutations commonly occur in patients with BCL 2/IgH rearrangements as a result of somatic hypermutation normally occurring at the IgH locus, and an algorithm designed to identify likely functionally relevant but infrequent mutations is identified as likely drivers of DLBCL pathogenesis in some patients.
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Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival.
Anne J. Novak,Anne J. Novak,Jaime R. Darce,Jaime R. Darce,Bonnie K. Arendt,Bonnie K. Arendt,Brandon Harder,Brandon Harder,Kathy Henderson,Kathy Henderson,Wayne R. Kindsvogel,Wayne R. Kindsvogel,Jane A. Gross,Jane A. Gross,Philip R. Greipp,Philip R. Greipp,Diane F. Jelinek,Diane F. Jelinek +17 more
TL;DR: Evidence that B-lymphocyte stimulator (BLyS) can modulate the proliferative capacity and survival of MM cells is provided and evidence that BLyS is expressed by MM cells and is present in the bone marrow of patients with MM.
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Intratumoral CD4+CD25+ regulatory T-cell-mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphoma
TL;DR: The results suggest that T(reg) cells are highly represented in the area of B-cell NHL and that malignant B cells are involved in the recruitment of these cells into the Area of lymphoma.
Journal ArticleDOI
An APRIL to remember: novel TNF ligands as therapeutic targets
TL;DR: This work focuses on APRIL, exploring its normal and pathological functions, and comparing the therapeutic molecules currently under development that target APRIL alone, or APRIL and BLyS/BAFF together.