G
Gerald Wulf
Researcher at University of Göttingen
Publications - 259
Citations - 10869
Gerald Wulf is an academic researcher from University of Göttingen. The author has contributed to research in topics: Transplantation & Internal medicine. The author has an hindex of 43, co-authored 218 publications receiving 9005 citations. Previous affiliations of Gerald Wulf include Center for Cell and Gene Therapy & Boston Children's Hospital.
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Journal ArticleDOI
A distinct "side population" of cells with high drug efflux capacity in human tumor cells.
C. Hirschmann-Jax,Aaron E. Foster,Gerald Wulf,Gerald Wulf,Jed G. Nuchtern,T. W. Jax,U. Gobel,Margaret A. Goodell,Malcolm K. Brenner +8 more
TL;DR: A distinct SP was found in neuroblastoma cells from 15 of 23 patients and showed evidence for asymmetric division, generating both SP and non-SP progeny, suggesting that this phenotype defines a class of cancer stem cells with inherently high resistance to chemotherapeutic agents that should be targeted during the treatment of malignant disease.
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Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes
Bjoern Chapuy,Chip Stewart,Andrew Dunford,Jaegil Kim,Atanas Kamburov,Robert A. Redd,Michael S. Lawrence,Michael S. Lawrence,Margaretha G.M. Roemer,Amy Li,Marita Ziepert,Annette M. Staiger,Annette M. Staiger,Jeremiah Wala,Matthew D. Ducar,Ignaty Leshchiner,Ester Rheinbay,Amaro Taylor-Weiner,Caroline A. Coughlin,Julian M. Hess,Chandra Sekhar Pedamallu,Dimitri Livitz,Daniel Rosebrock,Mara Rosenberg,Adam Tracy,Heike Horn,Paul Van Hummelen,Andrew L. Feldman,Brian K. Link,Anne J. Novak,James R. Cerhan,Thomas M. Habermann,Reiner Siebert,Andreas Rosenwald,Aaron R. Thorner,Matthew Meyerson,Matthew Meyerson,Todd R. Golub,Todd R. Golub,Rameen Beroukhim,Rameen Beroukhim,Gerald Wulf,German Ott,Scott J. Rodig,Scott J. Rodig,Stefano Monti,Donna Neuberg,Markus Loeffler,Michael Pfreundschuh,Lorenz Trümper,Gad Getz,Gad Getz,Margaret A. Shipp +52 more
TL;DR: A comprehensive genetic analysis of 304 primary DLBCLs identified low-frequency alterations, captured recurrent mutations, somatic copy number alterations, and structural variants, and defined coordinate signatures in patients with available outcome data to provide a roadmap for an actionableDLBCL classification.
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Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1
TL;DR: It is reported that Pin1 is strikingly overexpressed in human breast cancers, and that its levels correlate with cyclin D1 levels in tumors, and the results suggest that overexpression of Pin1 may promote tumor growth.
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In Vitro-Differentiated Embryonic Stem Cells Give Rise to Male Gametes that Can Generate Offspring Mice
Karim Nayernia,Jessica Nolte,H. W. Michelmann,Jae Ho Lee,Kristina Rathsack,Nadja Drusenheimer,Arvind Dev,Gerald Wulf,Ingrid Ehrmann,David J. Elliott,Vera Okpanyi,Ulrich Zechner,Thomas Haaf,Andreas Meinhardt,Wolfgang Engel +14 more
TL;DR: This approach provides an accessible in vitro model system for studies of mammalian gametogenesis, as well as for the development of new strategies for the generation of transgenic mice and treatment of infertility.
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A leukemic stem cell with intrinsic drug efflux capacity in acute myeloid leukemia.
Gerald Wulf,Rui Yu Wang,Rui Yu Wang,Ingrid Kuehnle,Ingrid Kuehnle,Douglas Weidner,Douglas Weidner,Frank C. Marini,Frank C. Marini,Malcolm K. Brenner,Michael Andreeff,Michael Andreeff,Margaret A. Goodell,Margaret A. Goodell +13 more
TL;DR: Findings indicate that SP cells are frequently involved in human AML and may be a target for leukemic transformation and suggest a mechanism by which SP cells could escape the effects of cytostatic drugs and might eventually contribute to leukemia relapse.