Amy Li

TL;DR: A comprehensive genetic analysis of 304 primary DLBCLs identified low-frequency alterations, captured recurrent mutations, somatic copy number alterations, and structural variants, and defined coordinate signatures in patients with available outcome data to provide a roadmap for an actionableDLBCL classification.

TL;DR: It is concluded that cells with the phenotype alpha6bri10G7(dim) represent the epidermal stem cell population based on the demonstration that these cells exhibit the greatest regenerative capacity of any basal cells.

TL;DR: NLRC5 is identified as a transcriptional regulator, orchestrating the concerted expression of critical components in the MHC class I pathway, and induced the expression of β2-microglobulin, transporter associated with antigen processing, and large multifunctional protease, which are essential for M HC class I antigen presentation.

TL;DR: Interestingly, a proportion of basal cells that have begun to differentiate in vivo within the basal layer as determined by their expression of the differentiation-specific markers K10 and involucrin also retain high levels of activated beta1 integrin, but downregulate alpha6beta4 expression selectively (termed alpha6dimbeta1bri).

TL;DR: These studies identify a positive amplification loop in which AHR-dependent TDO2 expression contributes to endogenous AHR ligand production, and identify the net biologic effect of AHR activation by endogenous ligands is an increase in tumor cell migration, a measure of tumor aggressiveness.