Anne-Katrin Späte

TL;DR: This work shows that ManNAc derivatives containing a terminal alkene in the acyl side chain are metabolically incorporated into cell-surface sialic acids and can subsequently be labeled by the DARinv, and identifies monosubstituted (terminal) alkenes as a new class of chemical reporters.

TL;DR: It is demonstrated that the cell's biosynthetic machinery incorporates this non-natural mannosamine derivative into glycoconjugates that can, subsequently, be labeled within less than 10 min with a new sulfo-Cy3-tetrazine conjugate.

TL;DR: Protein-specific detection of the glycosylation of the intracellular proteins OGT, Foxo1, p53, and Akt1 in living cells is demonstrated with high contrast even in presence of a large excess of acceptor fluorophores by fluorescence lifetime imaging microscopy.

TL;DR: It is demonstrated that leukocyte subsets express distinct patterns of CCR7 sialylation that contribute to receptor signaling and fine‐tuning chemotactic responses.

TL;DR: Chelate stabilization of a titanium(IV)-salan alkoxide by ligand exchange with 2,6-pyridinedicarboxylic acid (dipic) resulted in heptacoordinate complex 3 which is not redox-active, stable on silica gel and has increased aqueous stability.