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Anne-Marie Lambeir
Researcher at University of Antwerp
Publications - 182
Citations - 8588
Anne-Marie Lambeir is an academic researcher from University of Antwerp. The author has contributed to research in topics: Dipeptidyl peptidase & Oligopeptidase. The author has an hindex of 48, co-authored 181 publications receiving 7802 citations. Previous affiliations of Anne-Marie Lambeir include Université catholique de Louvain & International Institute of Minnesota.
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Journal ArticleDOI
Dipeptidyl-peptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV.
TL;DR: The role of DPP IV/CD26 within the immune system is a combination of its exopeptidase activity and its interactions with different molecules to serve as a co-stimulatory molecule to influence T cell activity and to modulate chemotaxis.
Journal ArticleDOI
Kinetic Investigation of Chemokine Truncation by CD26/Dipeptidyl Peptidase IV Reveals a Striking Selectivity within the Chemokine Family
Anne-Marie Lambeir,Paul Proost,Christine Durinx,Gunther Bal,Kristel Senten,Koen Augustyns,Simon Scharpé,Jo Van Damme,Ingrid De Meester +8 more
TL;DR: The steady-state catalytic parameters for a relevant selection of chemokines previously reported to alter their chemotactic behavior due to CD26/dipeptidyl peptidase IV-catalyzed truncation are determined and reveal a striking selectivity for stromal cell-derived factor-1α (CXCL12) and macrophage-derived chemokine (CCL22).
Journal ArticleDOI
Molecular characterization of dipeptidyl peptidase activity in serum: soluble CD26/dipeptidyl peptidase IV is responsible for the release of X-Pro dipeptides.
Christine Durinx,Anne-Marie Lambeir,Eugene Bosmans,Jean-Bernard Falmagne,Raf Berghmans,Achiel Haemers,Simon Scharpé,Ingrid De Meester +7 more
TL;DR: It is shown here that 95% of the serum dipeptidyl peptidase activity is associated with a protein with ADA-binding properties, and the purified serum enzyme was confirmed as CD26.
Journal ArticleDOI
Amino-terminal truncation of chemokines by CD26/dipeptidyl-peptidase IV. Conversion of RANTES into a potent inhibitor of monocyte chemotaxis and HIV-1-infection.
Paul Proost,Ingrid De Meester,Dominique Schols,Sofie Struyf,Anne-Marie Lambeir,Anja Wuyts,Ghislain Opdenakker,Erik De Clercq,Simon Scharpé,Jo Van Damme +9 more
TL;DR: Proteolytic processing of RANTES by CD26/dipeptidyl-peptidase IV may constitute an important regulatory mechanism during anti-inflammatory and antiviral responses.
Journal ArticleDOI
Amino-terminal truncation of CXCR3 agonists impairs receptor signaling and lymphocyte chemotaxis, while preserving antiangiogenic properties
Paul Proost,Evemie Schutyser,Patricia Menten,Sofie Struyf,Anja Wuyts,Ghislain Opdenakker,Michel Detheux,Marc Parmentier,Christine Durinx,Anne-Marie Lambeir,Johan Neyts,Sandra Liekens,P. C. Maudgal,Alfons Billiau,Jo Van Damme +14 more
TL;DR: A negative feedback regulation by CD26/DPP IV in CX CR3-mediated chemotaxis without affecting the angiostatic potential of the CXCR3 ligands IP-10 and Mig is demonstrated.