A
Annelaure Damont
Researcher at Université Paris-Saclay
Publications - 43
Citations - 1461
Annelaure Damont is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: DPA-714 & Translocator protein. The author has an hindex of 18, co-authored 41 publications receiving 1170 citations. Previous affiliations of Annelaure Damont include University of Paris-Sud & IBM.
Papers
More filters
Journal ArticleDOI
Comparative Evaluation of the Translocator Protein Radioligands 11C-DPA-713, 18F-DPA-714, and 11C-PK11195 in a Rat Model of Acute Neuroinflammation
Fabien Chauveau,Nadja Van Camp,Frédéric Dollé,Bertrand Kuhnast,Françoise Hinnen,Annelaure Damont,Hervé Boutin,Michelle L. James,Michael Kassiou,Bertrand Tavitian +9 more
TL;DR: In vivo, 18F-DPA-714 appears to be an attractive alternative to 11C-PK11195 because of its increased bioavailability in brain tissue and its reduced nonspecific binding, and its labeling with 18F, the preferred PET isotope for radiopharmaceutical chemistry, favors its dissemination and wide clinical use.
Journal ArticleDOI
Evaluation of the PBR/TSPO Radioligand [18F]DPA-714 in a Rat Model of Focal Cerebral Ischemia
Abraham Martín,Raphaël Boisgard,Benoit Thézé,Nadja Van Camp,Bertrand Kuhnast,Annelaure Damont,Michael Kassiou,Frédéric Dollé,Bertrand Tavitian +8 more
TL;DR: Results show that in vivo PET imaging with [18F]DPA-714 provides accurate quantitative information of the time course of PBR/TSPO expression in experimental stroke.
Journal ArticleDOI
Current paradigm of the 18-kDa translocator protein (TSPO) as a molecular target for PET imaging in neuroinflammation and neurodegenerative diseases
Alex Sik Chung Ching,Bertrand Kuhnast,Annelaure Damont,Dirk Roeda,Bertrand Tavitian,Frédéric Dollé +5 more
TL;DR: This review focuses on the current concepts related to the TSPO, and discusses briefly on the status of its PET imaging related to neuroinflammation and neurodegenerative diseases in humans.
Journal ArticleDOI
Suspect and non-targeted screening of chemicals of emerging concern for human biomonitoring, environmental health studies and support to risk assessment: From promises to challenges and harmonisation issues.
Mariane Pourchet,Laurent Debrauwer,Jana Klánová,Elliott J. Price,Adrian Covaci,Noelia Caballero-Casero,Herbert Oberacher,Marja H. Lamoree,Annelaure Damont,François Fenaille,Jelle Vlaanderen,Jeroen Meijer,Martin Krauss,Denis Sarigiannis,Robert Barouki,Bruno Le Bizec,Jean-Philippe Antignac +16 more
TL;DR: An overview of the basic principles, promises and challenges of suspect and non-targeted screening approaches applied to human samples as this specific field introduce major specificities compared to other fields is presented.
Journal ArticleDOI
Radiosynthesis of [18F]DPA-714, a selective radioligand for imaging the translocator protein (18 kDa) with PET
Annelaure Damont,Françoise Hinnen,Bertrand Kuhnast,Marie-Anne Schöllhorn-Peyronneau,Michelle L. James,Christopher Luus,Bertrand Tavitian,Michael Kassiou,Frédéric Dollé +8 more
TL;DR: In this article, DPA-714 and its tosyloxy derivative (N,N-diethyl-2-(2-(4-(2-fluoroethoxy)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide) were synthesized using a simple one-step process, which has been fully automated on Zymate-XP robotic system.