Anouk C. Tengeler

TL;DR: Evidence of coordinated metaorganism diurnal rhythmicity is provided and jet-lag-induced dysbiosis in both mice and humans promotes glucose intolerance and obesity that are transferrable to germ-free mice upon fecal transplantation.

TL;DR: It is shown in mouse models of obesity and diabetes that hyperglycemia drives intestinal barrier permeability, through GLUT2-dependent transcriptional reprogramming of intestinal epithelial cells and alteration of tight and adherence junction integrity, which leads to systemic influx of microbial products and enhanced dissemination of enteric infection.

TL;DR: Analysis in zebrafish and human macrophage models of mycobacterial infection reveals that the DNA damage-regulated autophagy modulator DRAM1 functions downstream of pathogen recognition by the Toll-like receptor (TLR)/interleukin-1 receptor (IL1R)-MYD88-NF-κB innate immune sensing pathway to activate selective Autophagy.

TL;DR: It is demonstrated that altered microbial composition could be a driver of altered brain structure and function and concomitant changes in the animals’ behavior and may help to understand the mechanisms through which the gut microbiota contributes to the pathobiology of neurodevelopmental disorders.

TL;DR: The potential effect of nutritional components on gut microbial composition and brain function is examined, suggesting a certain vulnerability of the gut microbiota.