A
Anouk C. Tengeler
Researcher at Radboud University Nijmegen
Publications - 8
Citations - 1649
Anouk C. Tengeler is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Gut flora & Circadian rhythm. The author has an hindex of 7, co-authored 8 publications receiving 1196 citations. Previous affiliations of Anouk C. Tengeler include Weizmann Institute of Science & Leiden University.
Papers
More filters
Journal ArticleDOI
Transkingdom Control of Microbiota Diurnal Oscillations Promotes Metabolic Homeostasis
Christoph A. Thaiss,David Zeevi,Maayan Levy,Gili Zilberman-Schapira,Jotham Suez,Anouk C. Tengeler,Lior Abramson,Meirav Katz,Meirav Katz,Tal Korem,Niv Zmora,Yael Kuperman,Inbal E. Biton,Shlomit Gilad,Alon Harmelin,Hagit Shapiro,Zamir Halpern,Eran Segal,Eran Elinav +18 more
TL;DR: Evidence of coordinated metaorganism diurnal rhythmicity is provided and jet-lag-induced dysbiosis in both mice and humans promotes glucose intolerance and obesity that are transferrable to germ-free mice upon fecal transplantation.
Journal ArticleDOI
Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection.
Christoph A. Thaiss,Maayan Levy,Inna Grosheva,Danping Zheng,Eliran Soffer,Eran Blacher,Sofia Braverman,Anouk C. Tengeler,Oren Barak,Oren Barak,Maya Elazar,Rotem Ben-Zeev,Dana Lehavi-Regev,Meirav Katz,Meirav Pevsner-Fischer,Arieh Gertler,Zamir Halpern,Alon Harmelin,Suhail Aamar,Patricia Serradas,Alexandra Grosfeld,Hagit Shapiro,Benjamin Geiger,Eran Elinav +23 more
TL;DR: It is shown in mouse models of obesity and diabetes that hyperglycemia drives intestinal barrier permeability, through GLUT2-dependent transcriptional reprogramming of intestinal epithelial cells and alteration of tight and adherence junction integrity, which leads to systemic influx of microbial products and enhanced dissemination of enteric infection.
Journal ArticleDOI
The DNA Damage-Regulated Autophagy Modulator DRAM1 Links Mycobacterial Recognition via TLR-MYD88 to Autophagic Defense
Michiel van der Vaart,Cornelis J. Korbee,Gerda E. M. Lamers,Anouk C. Tengeler,Rohola Hosseini,Mariëlle C. Haks,Tom H. M. Ottenhoff,Herman P. Spaink,Annemarie H. Meijer +8 more
TL;DR: Analysis in zebrafish and human macrophage models of mycobacterial infection reveals that the DNA damage-regulated autophagy modulator DRAM1 functions downstream of pathogen recognition by the Toll-like receptor (TLR)/interleukin-1 receptor (IL1R)-MYD88-NF-κB innate immune sensing pathway to activate selective Autophagy.
Journal ArticleDOI
Gut microbiota from persons with attention-deficit/hyperactivity disorder affects the brain in mice.
Anouk C. Tengeler,Sarita A. Dam,Maximilian Wiesmann,Jilly Naaijen,Miranda van Bodegom,Clara Belzer,Pieter J. Dederen,Vivienne Verweij,Barbara Franke,Tamas Kozicz,Tamas Kozicz,Alejandro Arias Vasquez,Amanda J. Kiliaan +12 more
TL;DR: It is demonstrated that altered microbial composition could be a driver of altered brain structure and function and concomitant changes in the animals’ behavior and may help to understand the mechanisms through which the gut microbiota contributes to the pathobiology of neurodevelopmental disorders.
Journal ArticleDOI
Relationship between diet, the gut microbiota, and brain function
TL;DR: The potential effect of nutritional components on gut microbial composition and brain function is examined, suggesting a certain vulnerability of the gut microbiota.