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Anthony W.S. Chan
Researcher at Yerkes National Primate Research Center
Publications - 108
Citations - 5060
Anthony W.S. Chan is an academic researcher from Yerkes National Primate Research Center. The author has contributed to research in topics: Huntington's disease & Huntingtin. The author has an hindex of 37, co-authored 105 publications receiving 4615 citations. Previous affiliations of Anthony W.S. Chan include University of Missouri & Emory University.
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Towards a transgenic model of Huntington’s disease in a non-human primate
Shang Hsun Yang,Pei Hsun Cheng,Heather Banta,Karolina Piotrowska-Nitsche,Karolina Piotrowska-Nitsche,Jin Jing Yang,Eric C.H. Cheng,Brooke R. Snyder,Katherine Larkin,Jun Liu,Jack Orkin,Zhi Hui Fang,Yoland Smith,Jocelyne Bachevalier,Jocelyne Bachevalier,Stuart M. Zola,Shihua Li,Xiao-Jiang Li,Anthony W.S. Chan +18 more
TL;DR: Hallmark features of HD, including nuclear inclusions and neuropil aggregates, were observed in the brains of the HD transgenic monkeys, and the data suggest that it will be feasible to generate valuable non-human primate models of HD and possibly other human genetic diseases.
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Transgenic Monkeys Produced by Retroviral Gene Transfer into Mature Oocytes
TL;DR: In this article, the green fluorescent protein (GFP) transgene was detected by both direct and indirect fluorescence imaging from a fraternal set of twins, miscarried at 73 days.
Transgenic monkeys produced by retroviral gene transfer into mature oocytes. Science. 291, 309-312
TL;DR: Transgenic rhesus monkeys carrying the green fluorescent protein (GFP) gene were produced by injecting pseudotyped replication-defective retroviral vector into the perivitelline space of 224 mature rhesUS oocytes, later fertilized by intracytoplasmic sperm injection.
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A small molecule enhances RNA interference and promotes microRNA processing
Ge Shan,Yujing Li,Junliang Zhang,Wendi Li,Keith E. Szulwach,Ranhui Duan,Mohammad Ali Faghihi,Ahmad M. Khalil,Lianghua Lu,Zain Paroo,Anthony W.S. Chan,Zhangjie Shi,Qinghua Liu,Claes Wahlestedt,Chuan He,Peng Jin +15 more
TL;DR: It is demonstrated that the RNAi pathway can be modulated intracellularly by small molecules, and it is shown that the small-molecule enoxacin (Penetrex) enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs.
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Transgenic cattle produced by reverse-transcribed gene transfer in oocytes.
TL;DR: It is shown that reverse-transcribed gene transfer can take place in an oocyte in MII arrest of meiosis, leading to production of offspring, the majority of which are transgenic.