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Shang Hsun Yang
Researcher at National Cheng Kung University
Publications - 70
Citations - 2290
Shang Hsun Yang is an academic researcher from National Cheng Kung University. The author has contributed to research in topics: Huntington's disease & Transgene. The author has an hindex of 21, co-authored 65 publications receiving 1939 citations. Previous affiliations of Shang Hsun Yang include National Chung Hsing University & Yerkes National Primate Research Center.
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Journal ArticleDOI
Towards a transgenic model of Huntington’s disease in a non-human primate
Shang Hsun Yang,Pei Hsun Cheng,Heather Banta,Karolina Piotrowska-Nitsche,Karolina Piotrowska-Nitsche,Jin Jing Yang,Eric C.H. Cheng,Brooke R. Snyder,Katherine Larkin,Jun Liu,Jack Orkin,Zhi Hui Fang,Yoland Smith,Jocelyne Bachevalier,Jocelyne Bachevalier,Stuart M. Zola,Shihua Li,Xiao-Jiang Li,Anthony W.S. Chan +18 more
TL;DR: Hallmark features of HD, including nuclear inclusions and neuropil aggregates, were observed in the brains of the HD transgenic monkeys, and the data suggest that it will be feasible to generate valuable non-human primate models of HD and possibly other human genetic diseases.
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Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9
Yongchang Chen,Yinghui Zheng,Yu Kang,Weili Yang,Yuyu Niu,Xiangyu Guo,Zhuchi Tu,Chenyang Si,Hong Wang,Ruxiao Xing,Xiuqiong Pu,Shang Hsun Yang,Shihua Li,Weizhi Ji,Xiao-Jiang Li +14 more
TL;DR: The findings indicate that CRISPR/Cas9 can efficiently generate monkey models of human diseases, regardless of inheritance patterns, and the presence of degenerated muscle cells in newborn Cas9-targeted monkeys suggests that therapeutic interventions at the early disease stage may be effective at alleviating the myopathy.
Journal ArticleDOI
Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease
Chuan En Wang,Suzanne Tydlacka,Adam L. Orr,Shang Hsun Yang,Rona K. Graham,Michael R. Hayden,Shihua Li,Anthony W.S. Chan,Xiao-Jiang Li +8 more
TL;DR: The findings suggest that the neuropathological phenotypes of HD stem largely from the accumulation of N-terminal mutant htt fragments and that this accumulation is determined by htt context and cell-type-dependent clearance of mutant htt.
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Hypoxia-induced microRNA-20a expression increases ERK phosphorylation and angiogenic gene expression in endometriotic stromal cells
TL;DR: The findings provide the novel mechanism that not only functionally links together hypoxic stress, microRNA-20a expression, aberrant ERK phosphorylation, and angiogenesis but also demonstrates that miR20a is an important modulator in the development of endometriosis.
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miR-196a Ameliorates Phenotypes of Huntington Disease in Cell, Transgenic Mouse, and Induced Pluripotent Stem Cell Models
Pei Hsun Cheng,Chia Ling Li,Yu Fan Chang,Shaw Jeng Tsai,Yen Yu Lai,Anthony W.S. Chan,Chuan-Mu Chen,Shang Hsun Yang +7 more
TL;DR: Results show that manipulating miR-196a provides beneficial effects in HD, suggesting the potential therapeutical role of miRNAs inHD, andMechanisms of miR -196a in HD might be through the alteration of ubiquitin-proteasome systems, gliosis, cAMP response element-binding protein pathway, and several neuronal regulatory pathways in vivo.