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Antonio Calignano
Researcher at University of Naples Federico II
Publications - 5
Citations - 400
Antonio Calignano is an academic researcher from University of Naples Federico II. The author has contributed to research in topics: Agonist & Palmitoylethanolamide. The author has an hindex of 5, co-authored 5 publications receiving 377 citations.
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Acute intracerebroventricular administration of palmitoylethanolamide, an endogenous peroxisome proliferator-activated receptor-alpha agonist, modulates carrageenan-induced paw edema in mice.
Giuseppe D'Agostino,Giovanna La Rana,Roberto Russo,Oscar Sasso,Anna Iacono,Emanuela Esposito,Giuseppina Mattace Raso,Salvatore Cuzzocrea,Jesse Lo Verme,Daniele Piomelli,Rosaria Meli,Antonio Calignano +11 more
TL;DR: Central PEA administration significantly reduced the expression of the proinflammatory enzymes cyclooxygenase-2 and inducible nitric-oxide synthase, and it significantly restored carrageenan-induced PPAR-α reduction in the spinal cord, confirming the involvement of this transcriptional factor in the control of peripheral inflammation.
Journal ArticleDOI
Central administration of palmitoylethanolamide reduces hyperalgesia in mice via inhibition of NF-κB nuclear signalling in dorsal root ganglia
Giuseppe D'Agostino,Giovanna La Rana,Roberto Russo,Oscar Sasso,Anna Iacono,Emanuela Esposito,Giuseppina Mattace Raso,Salvatore Cuzzocrea,Jesse LoVerme,Daniele Piomelli,Rosaria Meli,Antonio Calignano +11 more
TL;DR: It is reported that intracerebroventricular administration of PEA 30 min before carrageenan injection markedly reduced mechanical hyperalgesia up to 24 h following inflammatory insult, suggesting a centrally mediated component for these drugs in controlling inflammatory pain.
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Synergistic antinociception by the cannabinoid receptor agonist anandamide and the PPAR-alpha receptor agonist GW7647
Roberto Russo,Jesse LoVerme,Giovanna La Rana,Giuseppe D'Agostino,Oscar Sasso,Antonio Calignano,Daniele Piomelli +6 more
TL;DR: A synergistic interaction between the endocannabinoid and PPAR-alpha systems that might be exploited clinically and identify a new pharmacological effect of the BK channel activator isopimaric acid are revealed.
Journal ArticleDOI
AM404, an anandamide transport inhibitor, reduces plasma extravasation in a model of neuropathic pain in rat: Role for cannabinoid receptors
G. La Rana,Roberto Russo,Giuseppe D'Agostino,Oscar Sasso,G. Mattace Raso,Anna Iacono,Rosaria Meli,Daniele Piomelli,Antonio Calignano +8 more
TL;DR: The efficacy of cannabinoids in controlling pain behaviour through the modulation of several pain mediators and markers of vascular reactivity, such as SP, CGRP, PGs and NO are demonstrated.
Journal ArticleDOI
Palmitoylethanolamide modulates pentobarbital-evoked hypnotic effect in mice: involvement of allopregnanolone biosynthesis.
Oscar Sasso,Giovanna La Rana,S. Vitiello,S. Vitiello,Roberto Russo,Giuseppe D'Agostino,Anna Iacono,Emilio Russo,Rita Citraro,Salvatore Cuzzocrea,Pier Vincenzo Piazza,Pier Vincenzo Piazza,Giovanbattista De Sarro,Rosaria Meli,Antonio Calignano +14 more
TL;DR: This paper showed that exogenous administration of PEA, through a PPAR-alpha-dependent mechanism, modulates neurosteroid formation increasing ALLO levels and leading to a positive modulation of GABA(A) receptor.