Occurrence, Biogenesis, and Synthesis of Biologically Active Carbazole Alkaloids

https://rua.ua.es/dspace/bitstream/10045/62171/5/2016_Alonso_etal_EurJOC_rev.pdf

Deep Eutectic Solvents: The Organic Reaction Medium of the Century

Agricultural Salinity Assessment and Management

Recent developments on ultrasound assisted catalyst-free organic synthesis.

Murraya koenigii leaves (Rutaceae) are used traditionally in Indian Ayurvedic system to treat diabetes. The purpose of the study is to investigate the effect of mahanimbine (carbazole alkaloid from Murraya koenigii leaves) on blood glucose and serum lipid profiles on streptozotocin-induced diabetic rats. Diabetes was induced in adult male Wistar rats by intra-peritoneal injection of streptozotocin (45mg/kg). Mahanimbine (50 and 100mg/kg) were administrated as a single dose per week to the diabetic rats for 30 days. The control group received 0.3% w/v sodium carboxy methyl cellulose for the same duration. Fasting blood sugar and serum lipid profiles were measured in the diabetic and non-diabetic rats. In addition, in vitro alpha amylase and alpha glucosidase inhibitory effects of mahanimbine were performed. Results: In the diabetic rats, the elevated fasting blood sugar, triglycerides, low density lipoprotein, very low density lipoprotein levels were reduced and high density lipoprotein level was increased by mahanimbine at a dose of 50 and 100mg/kg (i.p). In addition, mahanimbine showed appreciable alpha amylase inhibitory effect and weak alpha glucosidase inhibitory effects when compared with acarbose. Conclusions: The present study indicated that mahanimbine possess anti-hyperglycemic and anti-lipidemic effects. Thus results suggesting mahanimbine has beneficial effect in the management of diabetes associated with abnormal lipid profile and related cardiovascular complications. Keywords: Streptozotocin; Hypoglycemic; Hypolipidemic; Mahanimbine

http://arjournals.org/index.php/ijpm/article/viewFile/82/76

Antidiabetic and hypolipidemic effects of mahanimbine (carbazole alkaloid) from murraya koenigii (rutaceae) leaves

A clean and expedient synthesis of spirooxindoles in aqueous media catalyzed over nanocrystalline MgO

Antidiarrhoeal activity of carbazole alkaloids from Murraya koenigii Spreng (Rutaceae) seeds

Sulfated titania catalyzed water mediated efficient synthesis of dicoumarols—a green approach

Murraya koenigii Spreng (Rutaceae), a medicinally important herb of Indian origin, has been used for centuries in the Ayurvedic System of Medicine. The leaves, bark and the roots of the plant are used in indigenous medicine as tonic, stomachic, stimulant and carminative. An infusion of the roasted leaves is used to prevent vomiting. The green tender leaves are eaten raw for the cure of dysentery. The juice of the root is taken to relieve pain associated with kidney ailments. The aim of the present review is to summarize the research related to the chemistry and pharmacology of this popular Indian Species.

/pdf/review-on-chemistry-and-pharmacology-of-murraya-koenigii-4ofy2bcmx4.pdf

Review on chemistry and pharmacology of Murraya koenigii Spreng (Rutaceae).

Bis(indol-3-yl)methanes have been synthesized at room temperature in high yields by the reaction of indole or 2-methylindole with aromatic aldehydes using the titanosilicate catalyst TiTUD-1 for the first time. The catalyst was recycled and reused five times with reproducible yields. This procedure has the advantage of high yields at room temperature, mildness of reaction conditions, operational simplicity and reusable nature of the catalyst which makes this protocol practically useful for the synthesis of bis(indol-3-yl)methanes.

A highly efficient, eco-friendly, room temperature synthesis of bis(indolyl)methanes using the mesoporous titanosilicate Ti-TUD-1: electrophilic substitution reactions of indoles - Part-XXXIII

Anupam Nayak

Papers

A clean and expedient synthesis of spirooxindoles in aqueous media catalyzed over nanocrystalline MgO

Antidiarrhoeal activity of carbazole alkaloids from Murraya koenigii Spreng (Rutaceae) seeds

Sulfated titania catalyzed water mediated efficient synthesis of dicoumarols—a green approach

Review on chemistry and pharmacology of Murraya koenigii Spreng (Rutaceae).

A highly efficient, eco-friendly, room temperature synthesis of bis(indolyl)methanes using the mesoporous titanosilicate Ti-TUD-1: electrophilic substitution reactions of indoles - Part-XXXIII