Showing papers by "Anuradha Lala published in 2017"
TL;DR: ivabradine selectively inhibits the funny current (If) in sinoatrial nodal tissue, resulting in a decrease in the rate of diastolic depolarization and, consequently, the heart rate, a mechanism that is distinct from those of other negative chronotropic agents.
106 citations
TL;DR: The advancements in engineering, implantation technique, and medical management detailed in this review will highlight the progress made toward achieving lifelong LVAD support and the challenges that remain.
82 citations
TL;DR: The key domains of primary palliative care for patients with HF are described and some specific ways in which primary pallingative care and specialist palliatives care can be offered in this population are offered.
Abstract: Heart failure (HF) is a chronic and progressive illness, which affects a growing number of adults, and is associated with a high morbidity and mortality, as well as significant physical and psychological symptom burden on both patients with HF and their families. Palliative care is the multidisciplinary specialty focused on optimizing quality of life and reducing suffering for patients and families facing serious illness, regardless of prognosis. Palliative care can be delivered as (1) specialist palliative care in which a palliative care specialist with subspecialty palliative care training consults or co-manages patients to address palliative needs alongside clinicians who manage the underlying illness or (2) as primary palliative care in which the primary clinician (such as the internist, cardiologist, cardiology nurse, or HF specialist) caring for the patient with HF provides the essential palliative domains. In this paper, we describe the key domains of primary palliative care for patients with HF and offer some specific ways in which primary palliative care and specialist palliative care can be offered in this population. Although there is little research on HF primary palliative care, primary palliative care in HF offers a key opportunity to ensure that this population receives high-quality palliative care in spite of the growing numbers of patients with HF as well as the limited number of specialist palliative care providers.
52 citations
TL;DR: The assessment of both the pattern and activity of myocardial injury has important implications for the clinical management of patients with cardiovascular disease and comprehensive evaluation of these has previously been challenging using a single imaging modality.
Abstract: The assessment of both the pattern and activity of myocardial injury has important implications for the clinical management of patients with cardiovascular disease. Comprehensive evaluation of these has previously been challenging using a single imaging modality.
Cardiac magnetic resonance (CMR)
50 citations
TL;DR: In this paper, patients with advanced heart failure (HF) enroll in hospice at low rates and data on their acute medical service utilization after hospice enrollment is limited, and patients with HF are admitted to the hospital at a low rate.
Abstract: Background—Patients with advanced heart failure (HF) enroll in hospice at low rates, and data on their acute medical service utilization after hospice enrollment is limited. Methods and Results—We ...
18 citations
TL;DR: In this large multicenter prospective study of major infections following cardiac surgery, CDI was encountered in nearly 1% of patients, was frequently diagnosed postdischarge, and was associated with extended length of stay and substantially increased mortality.
16 citations
TL;DR: Compared with 2004, there are fewer unanswered questions about how to use, adjust, and combine therapies and more questions about whether and how to stop therapies.
7 citations
01 Oct 2017
TL;DR: A proposed framework of multi-parametric 4D 18F-FDG PET/MR cardiac imaging may substantially improve ACS diagnosis by allowing a more accurate identification of positive ACS patterns in matched myocardium regions across LGE, SUV as well as Ki images and enabling the quantitative Ki-driven differentiation between true- and false-positive ACS indications for enhanced specificity.
Abstract: Cardiac involvement in sarcoidosis is currently under-diagnosed despite being the leading cause of death amongst sarcoidosis patients. Therefore, accurate and early diagnosis of subclinical but active cardiac sarcoidosis (ACS) is an important clinical goal. The recent advent of hybrid PET/MRI has enabled the multi-parametric and non-invasive evaluation of ACS in the myocardium at a significantly reduced radiation exposure. Although cardiac MRI with late gadolinium enhancement (LGE) may visualize the anatomical pattern of myocardial injury due to ACS, it cannot differentiate between active disease and old chronic scarring. On the other hand, 18FFDG PET standard uptake values (SUVs), which are used to identify regions of increased myocardial inflammation in patients with ACS, may not discriminate ACS-related inflammatory FDG signal, from high non-specific physiological FDG uptake, often leading to false positive ACS interpretation. In this study, we introduce a clinically feasible dynamic 18F-FDG PET/MR cardiac imaging protocol enabling the 4D analysis of the 18FFDG myocardial uptake pattern, coregistered with the LGE MR images. In addition, we employ advanced direct 4D Patlak parametric PET image reconstructions to deliver, beside standard semi-quantitative SUVs, highly quantitative images of the physiological parameters of FDG uptake rate (Ki), obtained directly from the complete 4D PET acquisition data, for enhanced robustness to statistical noise and Ki quantification. We believe that our proposed framework of multi-parametric 4D 18F-FDG PET/MR cardiac imaging may substantially improve ACS diagnosis by i) allowing a more accurate identification of positive ACS patterns in matched myocardium regions across LGE, SUV as well as Ki images and ii) enabling the quantitative Ki-driven differentiation between true- and false-positive ACS indications for enhanced specificity.
4 citations
Cedars-Sinai Medical Center1, Mount Sinai Hospital2, University of Pennsylvania3, University of Alabama at Birmingham4, Integris Baptist Medical Center5, University of Texas Southwestern Medical Center6, Virginia Commonwealth University7, Henry Ford Hospital8, University of Pittsburgh9, National Institutes of Health10, University of Michigan11, Brigham and Women's Hospital12, Washington University in St. Louis13
3 citations