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Aparna Ananthanarayanan
Researcher at Cornell University
Publications - 12
Citations - 178
Aparna Ananthanarayanan is an academic researcher from Cornell University. The author has contributed to research in topics: Microbiome & Biology. The author has an hindex of 5, co-authored 5 publications receiving 106 citations. Previous affiliations of Aparna Ananthanarayanan include Memorial Sloan Kettering Cancer Center.
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Journal ArticleDOI
Maternal Microbiome and Infections in Pregnancy.
Mohammed Amir,Julia A. Brown,Stephanie L. Rager,Katherine Z. Sanidad,Aparna Ananthanarayanan,Melody Y. Zeng +5 more
TL;DR: Light is shed on how dysregulation of the maternal microbiome may underlie obstetrical metabolic complications and infections in the mother and newborn that may be, in part, driven by maternal gut dysbiosis, and, lastly, common infections in pregnancy.
Journal ArticleDOI
ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors
Maria Skamagki,Cristina Correia,Percy Yeung,Timour Baslan,Samuel Beck,Cheng Zhang,Christian A. Ross,Lam Dang,Zhong Liu,Simona Giunta,Tzu-Pei Chang,Joye Wang,Aparna Ananthanarayanan,Martina Bohndorf,Benedikt Bosbach,James Adjaye,Hironori Funabiki,Jonghwan Kim,Scott W. Lowe,James J. Collins,Chi Wei Lu,Hu Li,Rui Zhao,Kitai Kim +23 more
TL;DR: It is demonstrated that A-iPSCs exhibit excessive glutathione-mediated reactive oxygen species (ROS) scavenging activity, which blocks the DNA damage response and apoptosis and permits survival of cells with genomic instability.
Journal ArticleDOI
Biological Significance of the Suppression of Oxidative Phosphorylation in Induced Pluripotent Stem Cells
Cheng Zhang,Maria Skamagki,Zhong Liu,Aparna Ananthanarayanan,Aparna Ananthanarayanan,Rui Zhao,Hu Li,Kitai Kim,Kitai Kim +8 more
TL;DR: It is discovered that induced pluripotent stem cell (iPSC) clones generated from aged tissue donors (A-iPSCs) fail to suppress oxidative phosphorylation, which generates higher levels of reactive oxygen species (ROS), which leads to excessive elevation of glutathione and blunted DNA damage response.
ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors
Maria Skamagki,Cristina Correia,Percy Yeung,Timour Baslan,Samuel Beck,Cheng Zhang,Christian A. Ross,Lam Dang,Zhong Liu,Simona Giunta,Tzu-Pei Chang,Joye Wang,Aparna Ananthanarayanan,Martina Bohndorf,Benedikt Bosbach,James Adjaye,Hironori Funabiki,Jonghwan Kim,Scott W. Lowe,Chi-Wei Lu,Hu Li,Rui Zhao,Kitai Kim,James J. Collins +23 more
Journal ArticleDOI
Gut microbiota-derived metabolites confer protection against SARS-CoV-2 infection
Julia A. Brown,Katherine Z. Sanidad,Serena Lucotti,Carol Miller Lieber,Robert M. Cox,Aparna Ananthanarayanan,Srijani Basu,Justin Chen,Mengrou Shan,Mohammed Amir,Fabian Schmidt,Yiska Weisblum,Michele Cioffi,Tingting Li,F. M. Rowdo,Chun-Jun Guo,Costas A. Lyssiotis,Brian Hayden,Andrew J. Dannenberg,Paul D. Bieniasz,Benhur Lee,Naohiro Inohara,Irina Matei,Richard K. Plemper,Melody Y. Zeng +24 more
TL;DR: Multiple pathways by which the gut microbiome protects mammalian hosts from SARS-CoV-2 intranasal infection are defined, both locally and systemically, via production of short-chain fatty acids (SCFAs).