J
James Adjaye
Researcher at University of Düsseldorf
Publications - 86
Citations - 1741
James Adjaye is an academic researcher from University of Düsseldorf. The author has contributed to research in topics: Induced pluripotent stem cell & Cellular differentiation. The author has an hindex of 18, co-authored 86 publications receiving 1264 citations. Previous affiliations of James Adjaye include Max Planck Society & King Saud University.
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Human stromal (mesenchymal) stem cells from bone marrow, adipose tissue and skin exhibit differences in molecular phenotype and differentiation potential.
May Al-Nbaheen,Radhakrishnan Vishnubalaji,Dalia Ali,Amel Bouslimi,Fawzi Al-Jassir,Matthias Megges,Alessandro Prigione,James Adjaye,James Adjaye,Moustapha Kassem,Moustapha Kassem,Abdullah Aldahmash,Abdullah Aldahmash +12 more
TL;DR: Compared with standard phenotype of human bone marrow MSC, MSC populations obtained from different tissues exhibit significant differences in their proliferation, differentiation and molecular phenotype, which should be taken into consideration when planning their use in clinical protocols.
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Human iPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological mtDNA Disorders.
Carmen Lorenz,Pierre Lesimple,Pierre Lesimple,Pierre Lesimple,Raul Bukowiecki,Annika Zink,Annika Zink,Gizem Inak,Barbara Mlody,Manvendra K. Singh,Marcus Semtner,Nancy Mah,Karine Auré,Karine Auré,Karine Auré,Megan Leong,Oleksandr Zabiegalov,Ekaterini-Maria Lyras,Vanessa Pfiffer,Beatrix Fauler,Jenny Eichhorst,Burkhard Wiesner,Norbert Huebner,Josef Priller,Thorsten Mielke,David Meierhofer,Zsuzsanna Izsvák,Jochen C. Meier,Frédéric Bouillaud,Frédéric Bouillaud,Frédéric Bouillaud,James Adjaye,Markus Schuelke,Erich E. Wanker,Anne Lombès,Anne Lombès,Anne Lombès,Alessandro Prigione +37 more
TL;DR: It is shown that neural progenitor cells derived from human induced pluripotent stem cells (iPSCs) retain the parental mtDNA profile and exhibit a metabolic switch toward oxidative phosphorylation, and that iPSC-derived NPCs provide an effective model for drug screening to target mtDNA disorders that affect the nervous system.
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Modeling Nonalcoholic Fatty Liver Disease with Human Pluripotent Stem Cell-Derived Immature Hepatocyte-Like Cells Reveals Activation of PLIN2 and Confirms Regulatory Functions of Peroxisome Proliferator-Activated Receptor Alpha
Nina Graffmann,Sarah Ring,Marie-Ann Kawala,Wasco Wruck,Audrey Ncube,Hans-Ingo Trompeter,James Adjaye +6 more
TL;DR: This study developed an in vitro model for NAFLD based on hepatocyte-like cells differentiated from human pluripotent stem cells and induced fat storage and detected major expression changes of metabolism-associated genes, as well as an overall reduction of liver-related microRNAs.
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Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature
Lucas-Sebastian Spitzhorn,Matthias Megges,Wasco Wruck,Shaifur Rahman,Jörg Otte,Özer Degistirici,Roland Meisel,Rüdiger V. Sorg,Richard O.C. Oreffo,James Adjaye +9 more
TL;DR: iMSCs irrespective of donor age and cell source acquire a rejuvenation gene signature, which could allow circumventing the drawbacks associated with the use of adult MSCs und thus provide a promising tool for use in various clinical settings in the future.
Journal ArticleDOI
Characterization of burn wound healing gel prepared from human amniotic membrane and Aloe vera extract
Shaifur Rahman,Rashedul Islam,Masud Rana,Lucas-Sebastian Spitzhorn,Mohammad Shahedur Rahman,James Adjaye,S. M. Asaduzzaman +6 more
TL;DR: It is demonstrated that a gel consisting of a combination of amnion and Aloe vera extract has high efficacy as a burn wound healing product.