A
Aram Megighian
Researcher at University of Padua
Publications - 83
Citations - 1815
Aram Megighian is an academic researcher from University of Padua. The author has contributed to research in topics: Skeletal muscle & Neuromuscular junction. The author has an hindex of 21, co-authored 67 publications receiving 1527 citations.
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Mitochondrial dysfunction and apoptosis in myopathic mice with collagen VI deficiency
William Irwin,Natascha Bergamin,Patrizia Sabatelli,Carlo Reggiani,Aram Megighian,Luciano Merlini,Paola Braghetta,Marta Columbaro,Dino Volpin,Giorgio M. Bressan,Paolo Bernardi,Paolo Bonaldo +11 more
TL;DR: It is shown that Col6a1−/− muscles have a loss of contractile strength associated with ultrastructural alterations of sarcoplasmic reticulum and mitochondria and spontaneous apoptosis, which indicates that collagen VI myopathies have an unexpected mitochondrial pathogenesis that could be exploited for therapeutic intervention.
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Thioredoxin and Its Reductase Are Present on Synaptic Vesicles, and Their Inhibition Prevents the Paralysis Induced by Botulinum Neurotoxins
Marco Pirazzini,Domenico Azarnia Tehran,Giulia Zanetti,Aram Megighian,Michele Scorzeto,Silvia Fillo,Clifford C. Shone,Thomas Binz,Ornella Rossetto,Florigio Lista,Cesare Montecucco +10 more
TL;DR: It is shown that the thiored toxin reductase-thioredoxin protein disulfide-reducing system is present on synaptic vesicles and that it is functional and responsible for the reduction of the interchain disulfides of botulinum neurotoxin serotypes A, C, and E.
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Denervation in murine fast-twitch muscle: short-term physiological changes and temporal expression profiling
Anna Raffaello,Paolo Laveder,Chiara Romualdi,Camilla Bean,Luana Toniolo,Elena Germinario,Aram Megighian,Daniela Danieli-Betto,Carlo Reggiani,Gerolamo Lanfranchi +9 more
TL;DR: It is concluded that, if studied at the mRNA level, fast muscles appear not less responsive than slow muscles to the interruption of neural stimulation.
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A Drosophila mutant of LETM1, a candidate gene for seizures in Wolf-Hirschhorn syndrome
Angus McQuibban,Nicholas Joza,Aram Megighian,Michele Scorzeto,Damiano Zanini,Siegfried Reipert,Constance Richter,Rudolf J. Schweyen,Karin Nowikovsky +8 more
TL;DR: In this paper, the effects of down-regulating the LETM1 gene on mitochondrial function were investigated in both Drosophila melanogaster cultured cells and the adult fly, and the results demonstrated the function of DmLETM1 as a mitochondrial osmoregulator.
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Collagen VI regulates peripheral nerve myelination and function
TL;DR: It is shown that Schwann cells, but not axons, contribute to collagen VI deposition in peripheral nerves, and results indicate that collagen VI is a critical component of PNS contributing to the structural integrity and proper function of peripheral nerves.