Constance Richter

TL;DR: Improved methods and detailed protocols make Cas9-mediated mutagenesis an attractive approach for labs of all sizes and increase rates of mutagenisation by implementing several novel approaches.

TL;DR: The study shows that parallel RNA interference and small molecule screening is a generally useful approach to identifying active small molecules and their target pathways and identifies a small molecule that inhibits the Aurora B kinase pathway.

TL;DR: A genome-scale RNA-mediated interference screen in HeLa cells designed to identify human genes that are important for cell division is reported, and two evolutionarily conserved transcriptional regulatory networks that govern cytokinesis are identified.

TL;DR: The data identify key roles for the chromatin remodeling Brm complex, the spliceosome, and the TRiC/CCT-complex and show that the alternatively spliced transcription factor Lola and the transcriptional elongation factors Ssrp and Barc control self-renewal in neuroblast lineages.

TL;DR: Cep192, the human homolog of C. elegans SPD-2 and mammalian NEDD-1 (GCP-WD) are key regulators of PCM recruitment, centrosome maturation, and centriole duplication in mammalian cells and are proposed as a model in which Cep192 and Pericentrin are mutually dependent for their localization to mitotic centrosomes during centrosomal maturation.