Arianna Carolina Rosa

TL;DR: All four histamine receptors in human renal tubules are identified, particularly the H4R, which was partially suppressed by the selective H2R, H3R and H 4R antagonists when each added alone, and completely ablated when combined together.

TL;DR: This review provides an update on histamine, on diamine oxidase (DAO) and on their implications in allergy and various conditions or affections, such as food histaminosis, ischemia and inflammatory bowel diseases (IBD).

TL;DR: The data suggest that the H4R participates in diabetic nephropathy progression through both a direct effect on tubular reabsorption and an indirect action on renal tissue architecture via inflammatory cell recruitment, and H 4R antagonism emerges as a possible new multi‐mechanism therapeutic approach to counteract development of diabetic neephropathy development.

TL;DR: This work investigated the ability of natural and synthetic selective NK receptors agonists and antagonists to modulate cyclooxygenase‐2 (COX‐2) expression in human polymorphonuclear leucocytes (PMNs).

TL;DR: The results here reported clearly demonstrated that H4R ligands have a beneficial effect in a model of lung fibrosis in the mouse, thus indicating that H 4R antagonists or inverse agonists could be a novel therapeutic strategy for lung inflammatory diseases.