A
Arianna Gigoni
Researcher at University of Genoa
Publications - 7
Citations - 268
Arianna Gigoni is an academic researcher from University of Genoa. The author has contributed to research in topics: Non-coding RNA & Gene. The author has an hindex of 5, co-authored 7 publications receiving 231 citations.
Papers
More filters
Journal ArticleDOI
An intronic ncRNA-dependent regulation of SORL1 expression affecting Aβ formation is upregulated in post-mortem Alzheimer's disease brain samples
Eleonora Ciarlo,Sara Massone,Ilaria Penna,Mario Nizzari,Arianna Gigoni,Giorgio Dieci,Claudio Russo,Tullio Florio,Ranieri Cancedda,Aldo Pagano +9 more
TL;DR: 51A expression drives a splicing shift of SORL1 from the synthesis of the canonical long protein variant A to an alternatively spliced protein form, which is associated with impaired processing of amyloid precursor protein (APP), leading to increased Aβ formation.
Journal ArticleDOI
Selection of Candidate Housekeeping Genes for Normalization in Human Postmortem Brain Samples
TL;DR: The aim of this study is to identify the most stable genes in postmortem human brain samples of patients affected by Alzheimer’s disease suitable as reference genes and it is found that CYC1 and EIF4A2 are the best reference genes.
Journal ArticleDOI
Metformin inhibition of neuroblastoma cell proliferation is differently modulated by cell differentiation induced by retinoic acid or overexpression of NDM29 non-coding RNA
TL;DR: The data suggest the efficacy of metformin as neuroblastoma anticancer agent, and support the requirement of further studies on the possible role of the differentiation status on the antiproliferative effects of this drug.
Journal ArticleDOI
The inhibition of 45A ncRNA expression reduces tumor formation, affecting tumor nodules compactness and metastatic potential in neuroblastoma cells.
Ilaria Penna,Arianna Gigoni,Delfina Costa,Serena Vella,Debora Russo,Alessandro Poggi,Federico Villa,Antonella Brizzolara,Claudio Canale,Andrea Mescola,Antonio Daga,Claudio Russo,Mario Nizzari,Tullio Florio,Paola Menichini,Aldo Pagano +15 more
TL;DR: In conclusion, the data highlight a key role of 45A ncRNA in cancer development and suggest that its modulation might represent a possible novel anticancer therapeutic approach.
Journal ArticleDOI
Generation of a Functional Human Neural Network by NDM29 Overexpression in Neuroblastoma Cancer Cells.
Susanna Alloisio,Patrizia Garbati,Federica Viti,Silvia Dante,Raffaella Barbieri,Giovanni Arnaldi,Alessia Petrelli,Arianna Gigoni,Paolo Giannoni,Rodolfo Quarto,Mario Nobile,Massimo Vassalli,Aldo Pagano +12 more
TL;DR: A human functionally active neural network derived by human neuroblastoma cancer cells genetically engineered to overexpress NDM29, a non-coding RNA whose increased synthesis causes the differentiation toward a neuronal phenotype is developed.