Arja Reinikainen

TL;DR: Serum metabolite profiles were compared between sample series drawn from children who progressed to type 1 diabetes and controls who remained nondiabetic and permanently autoantibody negative, finding that autoimmunity may be a relatively late response to the early metabolic disturbances.

TL;DR: It is shown that PARP-14 plays a fundamental role mediating protection against apoptosis in IL-4-treated B cells, including that after DNA damage, and mediates IL- 4 effects on the levels of gene products that regulate cell survival, proliferation, and lymphomagenesis.

TL;DR: The findings suggest that the role of AIRE in the DCs differs from its function in the thymus, and the ERK signal transduction pathway is identified as a candidate for mediating the signal that results in the altered expression profile.

TL;DR: Results show that the actin-binding domain of Abl enhances leukemia development but does not appear to be an absolute requirement for leukemogenesis.

TL;DR: Results suggest that, during persistent infection, C. pneumoniae reprograms the host transcriptional machinery that regulates a variety of cellular processes, including adhesion, regulation of the cell cycle, growth, and inflammatory response, all of which might play important roles in the pathogenesis of persistent C.neumoniae infection.