O
Olli Simell
Researcher at Turku University Hospital
Publications - 484
Citations - 26833
Olli Simell is an academic researcher from Turku University Hospital. The author has contributed to research in topics: Type 1 diabetes & Diabetes mellitus. The author has an hindex of 82, co-authored 481 publications receiving 24415 citations. Previous affiliations of Olli Simell include JDRF & University of Turku.
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Journal ArticleDOI
Seroconversion to Multiple Islet Autoantibodies and Risk of Progression to Diabetes in Children
Anette-G. Ziegler,Marian Rewers,Olli Simell,Tuula Simell,Johanna Lempainen,Andrea K. Steck,Christiane Winkler,Jorma Ilonen,Riitta Veijola,Mikael Knip,Ezio Bonifacio,George S. Eisenbarth +11 more
TL;DR: The majority of children at risk of type 1 diabetes who had multiple islet autoantibody seroconversion progressed to diabetes over the next 15 years, and future prevention studies should focus on this high-risk population.
Journal ArticleDOI
Toward defining the autoimmune microbiome for type 1 diabetes
Adriana Giongo,Kelsey A. Gano,David B. Crabb,Nabanita Mukherjee,Luis G Leon Novelo,George Casella,Jennifer C. Drew,Jorma Ilonen,Jorma Ilonen,Jorma Ilonen,Mikael Knip,Mikael Knip,Heikki Hyöty,Heikki Hyöty,R. Veijola,R. Veijola,Tuula Simell,Tuula Simell,Olli Simell,Olli Simell,Josef Neu,Clive Wasserfall,Desmond A. Schatz,Mark A. Atkinson,Eric W. Triplett +24 more
TL;DR: Three lines of evidence are presented that support the notion that, as healthy infants approach the toddler stage, their microbiomes become healthier and more stable, whereas, children who are destined for autoimmunity develop a microbiome that is less diverse and stable.
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Gut Microbiome Metagenomics Analysis Suggests a Functional Model for the Development of Autoimmunity for Type 1 Diabetes
Christopher T. Brown,Austin G. Davis-Richardson,Adriana Giongo,Kelsey A. Gano,David B. Crabb,Nabanita Mukherjee,George Casella,Jennifer C. Drew,Jorma Ilonen,Mikael Knip,Heikki Hyöty,Riitta Veijola,Tuula Simell,Olli Simell,Josef Neu,Clive Wasserfall,Desmond A. Schatz,Mark A. Atkinson,Eric W. Triplett +18 more
TL;DR: Detailed differences in metabolic potential indicate that autoimmune subjects have a functionally aberrant microbiome, and data suggest that a consortium of lactate- and butyrate-producing bacteria in a healthy gut induce a sufficient amount of mucin synthesis to maintain gut integrity.
Journal ArticleDOI
Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes.
Matej Orešič,Satu Simell,Marko Sysi-Aho,Kirsti Näntö-Salonen,Tuulikki Seppänen-Laakso,Vilhelmiina Parikka,Mikko Katajamaa,Anne Hekkala,Ismo Mattila,Päivi Keskinen,Laxman Yetukuri,Arja Reinikainen,Jyrki Lähde,Tapani Suortti,Jari Hakalax,Tuula Simell,Heikki Hyöty,Riitta Veijola,Jorma Ilonen,Jorma Ilonen,Riitta Lahesmaa,Mikael Knip,Olli Simell +22 more
TL;DR: Serum metabolite profiles were compared between sample series drawn from children who progressed to type 1 diabetes and controls who remained nondiabetic and permanently autoantibody negative, finding that autoimmunity may be a relatively late response to the early metabolic disturbances.
Journal ArticleDOI
Maternal vitamin D intake during pregnancy is inversely associated with asthma and allergic rhinitis in 5-year-old children
Maijaliisa Erkkola,Minna Kaila,Bright I Nwaru,C. Kronberg-Kippila,Suvi Ahonen,Jaakko Nevalainen,Riitta Veijola,J Pekkanen,Jorma Ilonen,Jorma Ilonen,Olli Simell,Mikael Knip,Suvi M. Virtanen +12 more
TL;DR: Background Vitamin D is known to have a number of immunological effects and it may play a role in preventing allergic diseases.