M
Mikael Knip
Researcher at University of Helsinki
Publications - 827
Citations - 45622
Mikael Knip is an academic researcher from University of Helsinki. The author has contributed to research in topics: Type 1 diabetes & Diabetes mellitus. The author has an hindex of 105, co-authored 784 publications receiving 40829 citations. Previous affiliations of Mikael Knip include University of Tampere & University of Colorado Boulder.
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Journal ArticleDOI
Prevalence of Celiac disease among children in Finland.
Markku Mäki,K. Mustalahti,Jorma Kokkonen,Petri Kulmala,Mila Haapalahti,Tuomo J. Karttunen,Jorma Ilonen,Kaija Laurila,Ingrid Dahlbom,Tony Hansson,Peter Höpfl,Mikael Knip +11 more
TL;DR: The presence of serum tissue transglutaminase and endomysial autoantibodies is predictive of small-bowel abnormalities indicative of celiac disease and there is a good correlation betweenAutoantibody positivity and specific HLA haplotypes.
Journal ArticleDOI
Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans
Tommi Vatanen,Tommi Vatanen,Aleksandar Kostic,Aleksandar Kostic,Eva d'Hennezel,Heli Siljander,Eric A. Franzosa,Eric A. Franzosa,Moran Yassour,Raivo Kolde,Hera Vlamakis,Timothy D. Arthur,Anu Maaria Hämäläinen,Aleksandr Peet,Vallo Tillmann,Raivo Uibo,Sergei Mokurov,Natalya Dorshakova,Jorma Ilonen,Jorma Ilonen,Suvi M. Virtanen,Suvi M. Virtanen,Susanne J. Szabo,Jeffrey A. Porter,Harri Lähdesmäki,Curtis Huttenhower,Curtis Huttenhower,Dirk Gevers,Thomas W. Cullen,Mikael Knip,Ramnik J. Xavier +30 more
TL;DR: It is shown that Bacteroides LPS is structurally distinct from E. coli LPS and inhibits innate immune signaling and endotoxin tolerance, and that early colonization by immunologically silencing microbiota may preclude aspects of immune education.
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The Dynamics of the Human Infant Gut Microbiome in Development and in Progression toward Type 1 Diabetes
Aleksandar Kostic,Aleksandar Kostic,Dirk Gevers,Heli Siljander,Tommi Vatanen,Tommi Vatanen,Tuulia Hyötyläinen,Tuulia Hyötyläinen,Anu-Maaria Hämäläinen,Aleksandr Peet,Vallo Tillmann,Päivi Pöhö,Päivi Pöhö,Ismo Mattila,Ismo Mattila,Harri Lähdesmäki,Eric A. Franzosa,Outi Vaarala,Marcus C. de Goffau,Hermie J. M. Harmsen,Jorma Ilonen,Jorma Ilonen,Suvi M. Virtanen,Suvi M. Virtanen,Clary B. Clish,Matej Orešič,Matej Orešič,Curtis Huttenhower,Curtis Huttenhower,Mikael Knip,Ramnik J. Xavier +30 more
TL;DR: Trends in the development of the human infant gut microbiome along with specific alterations that precede T1D onset and distinguish T2D progressors from nonprogressors are identified.
Journal ArticleDOI
Seroconversion to Multiple Islet Autoantibodies and Risk of Progression to Diabetes in Children
Anette-G. Ziegler,Marian Rewers,Olli Simell,Tuula Simell,Johanna Lempainen,Andrea K. Steck,Christiane Winkler,Jorma Ilonen,Riitta Veijola,Mikael Knip,Ezio Bonifacio,George S. Eisenbarth +11 more
TL;DR: The majority of children at risk of type 1 diabetes who had multiple islet autoantibody seroconversion progressed to diabetes over the next 15 years, and future prevention studies should focus on this high-risk population.
Journal ArticleDOI
Toward defining the autoimmune microbiome for type 1 diabetes
Adriana Giongo,Kelsey A. Gano,David B. Crabb,Nabanita Mukherjee,Luis G Leon Novelo,George Casella,Jennifer C. Drew,Jorma Ilonen,Jorma Ilonen,Jorma Ilonen,Mikael Knip,Mikael Knip,Heikki Hyöty,Heikki Hyöty,R. Veijola,R. Veijola,Tuula Simell,Tuula Simell,Olli Simell,Olli Simell,Josef Neu,Clive Wasserfall,Desmond A. Schatz,Mark A. Atkinson,Eric W. Triplett +24 more
TL;DR: Three lines of evidence are presented that support the notion that, as healthy infants approach the toddler stage, their microbiomes become healthier and more stable, whereas, children who are destined for autoimmunity develop a microbiome that is less diverse and stable.