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Arleen D. Auerbach
Researcher at Rockefeller University
Publications - 134
Citations - 11167
Arleen D. Auerbach is an academic researcher from Rockefeller University. The author has contributed to research in topics: Fanconi anemia & FANCA. The author has an hindex of 50, co-authored 131 publications receiving 10551 citations. Previous affiliations of Arleen D. Auerbach include Icahn School of Medicine at Mount Sinai & Medical College of Wisconsin.
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Journal ArticleDOI
Somatic mosaicism in Fanconi anemia: Evidence of genotypic reversion in lymphohematopoietic stem cells
John J. Gregory,John E. Wagner,Peter C. Verlander,Orna Levran,Sat Dev Batish,Cindy R. Eide,Amy Steffenhagen,Betsy A. Hirsch,Arleen D. Auerbach +8 more
TL;DR: The spontaneous genotypic reversion in a lymphohematopoietic stem cell is demonstrated and the subsequent development of a clonal cytogenetic abnormality in nonrevertant cells suggests that ex vivo correction of hematopoetic stem cells by gene transfer may not be sufficient for providing life-long stable hematOPoiesis in patients with FA.
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Germline Mutations in BRCA2: Shared Genetic Susceptibility to Breast Cancer, Early Onset Leukemia and Fanconi Anemia
John E. Wagner,Jakub Tolar,Orna Levran,Thomas Scholl,Amie M. Deffenbaugh,Jaya M. Satagopan,Leah Ben-Porat,Katherine Mah,Sat Dev Batish,David I. Kutler,Margaret L. MacMillan,Helmut Hanenberg,Arleen D. Auerbach +12 more
TL;DR: The results suggest that BRCA2 testing should be considered in all patients with FA in whom the complementation group cannot be defined or in whom leukemia is diagnosed at or before 5 years of age.
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Shared Genetic Susceptibility to Breast Cancer, Brain Tumors, and Fanconi Anemia
Kenneth Offit,Orna Levran,Brian Mullaney,Katherine Mah,Khedoudja Nafa,Sat Dev Batish,Raffaella Diotti,Hildegard Schneider,Amie M. Deffenbaugh,Thomas Scholl,Virginia K. Proud,Mark E. Robson,Larry Norton,Nathan A. Ellis,Helmut Hanenberg,Arleen D. Auerbach +15 more
TL;DR: The co-occurrence of brain tumors, Fanconi anemia, and breast cancer observed in one of these kindreds constitutes a new syndromic association and individuals who carry a germline BRCA2 mutation and who plan to have children with a partner of Ashkenazi Jewish descent should consider undergoing genetic counseling.
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Unrelated donor bone marrow transplantation for the treatment of Fanconi anemia
John E. Wagner,Mary Eapen,Margaret L. MacMillan,Richard E. Harris,Ricardo Pasquini,Farid Boulad,Mei-Jie Zhang,Arleen D. Auerbach +7 more
TL;DR: Significant practice changes are suggested: use of a fludarabine-containing conditioning regimen in the context of T-cell-depleted marrow allografts, and earlier referral for transplantation prior to excessive transfusions in patients with marrow failure.
Journal ArticleDOI
Stem Cell Collection and Gene Transfer in Fanconi Anemia
Patrick Kelly,Susan Radtke,Christof von Kalle,Brenden Balcik,Kimberley Bohn,Robin Mueller,Todd Schuesler,Moira Haren,Lilith Reeves,Jose A. Cancelas,Jose A. Cancelas,Thomas Leemhuis,Richard E. Harris,Arleen D. Auerbach,Franklin O. Smith,Stella M. Davies,David A. Williams +16 more
TL;DR: It is reported that FA patients have significant depletion of their BMCD34+ cell compartment even before severe pancytopenia is present, and oncoretroviral-mediated ex vivo gene transfer was efficient in clinical scale in FA-A cells, leading to reversal of the cellular phenotype in a significant percentage of CD34+ cells.