A
Arnold Kas
Researcher at University of Washington
Publications - 16
Citations - 7503
Arnold Kas is an academic researcher from University of Washington. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 12, co-authored 16 publications receiving 7064 citations. Previous affiliations of Arnold Kas include Howard Hughes Medical Institute & Benaroya Research Institute.
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Journal ArticleDOI
Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.
Charles K. Stover,X. Q. Pham,A. L. Erwin,S. D. Mizoguchi,Paul Warrener,Mark J. Hickey,Fiona S. L. Brinkman,W. O. Hufnagle,D. J. Kowalik,Lagrou Mj,R. L. Garber,L. Goltry,E. Tolentino,S. Westbrock-Wadman,Ying Yuan,L. L. Brody,S. N. Coulter,K. R. Folger,Arnold Kas,K. Larbig,R. Lim,Kelly D. Smith,David H. Spencer,Gane Ka-Shu Wong,Z. Wu,Ian T. Paulsen,Ian T. Paulsen,Jonathan Reizer,Milton H. Saier,Robert E. W. Hancock,Stephen Lory,Maynard V. Olson +31 more
TL;DR: It is proposed that the size and complexity of the P. aeruginosa genome reflect an evolutionary adaptation permitting it to thrive in diverse environments and resist the effects of a variety of antimicrobial substances.
Journal ArticleDOI
CD4+ Regulatory T Cells Control TH17 Responses in a Stat3-Dependent Manner
Ashutosh Chaudhry,Dipayan Rudra,Dipayan Rudra,Piper M. Treuting,Robert M. Samstein,Yuqiong Liang,Arnold Kas,Alexander Y. Rudensky,Alexander Y. Rudensky +8 more
TL;DR: The findings suggest that Tregs adapt to their environment by engaging distinct effector response–specific suppression modalities upon activation of STAT proteins that direct the corresponding class of the immune response.
Journal ArticleDOI
Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T H 2 responses
Ye Zheng,Ashutosh Chaudhry,Ashutosh Chaudhry,Arnold Kas,Paul deRoos,Paul deRoos,Jeong M. Kim,Tin-Tin Chu,Lynn M. Corcoran,Piper M. Treuting,Ulf Klein,Alexander Y. Rudensky,Alexander Y. Rudensky +12 more
TL;DR: The results indicate that Treg cells use components of the transcriptional machinery, promoting a particular type of effector CD4+ T cell differentiation, to efficiently restrain the corresponding type of the immune response.
Journal ArticleDOI
Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells
Ye Zheng,Steven Z. Josefowicz,Arnold Kas,Tin-Tin Chu,Marc A. Gavin,Marc A. Gavin,Alexander Y. Rudensky,Alexander Y. Rudensky +7 more
TL;DR: In this article, a genome-wide analysis combining chromatin immunoprecipitation with mouse genome tiling array profiling was performed to identify Foxp3 binding regions for approximately 700 genes and for an intergenically encoded microRNA.
Journal ArticleDOI
Whole-Genome Sequence Variation among Multiple Isolates of Pseudomonas aeruginosa
David H. Spencer,Arnold Kas,Eric E. Smith,Christopher K. Raymond,Elizabeth H. Sims,Michele Hastings,Jane L. Burns,Jane L. Burns,Rajinder Kaul,Maynard V. Olson +9 more
TL;DR: It is concluded that most of the PAO1 genome represents a core P. aeruginosa backbone sequence while the strains addressed in this study possess additional genetic material that accounts for at least 10% of their genomes, and approximately half of these additional sequences are novel.