D
David H. Spencer
Researcher at Washington University in St. Louis
Publications - 80
Citations - 13851
David H. Spencer is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Gene & Myeloid leukemia. The author has an hindex of 26, co-authored 68 publications receiving 12071 citations. Previous affiliations of David H. Spencer include Albert Einstein College of Medicine & Barnes-Jewish Hospital.
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Journal ArticleDOI
Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.
Charles K. Stover,X. Q. Pham,A. L. Erwin,S. D. Mizoguchi,Paul Warrener,Mark J. Hickey,Fiona S. L. Brinkman,W. O. Hufnagle,D. J. Kowalik,Lagrou Mj,R. L. Garber,L. Goltry,E. Tolentino,S. Westbrock-Wadman,Ying Yuan,L. L. Brody,S. N. Coulter,K. R. Folger,Arnold Kas,K. Larbig,R. Lim,Kelly D. Smith,David H. Spencer,Gane Ka-Shu Wong,Z. Wu,Ian T. Paulsen,Ian T. Paulsen,Jonathan Reizer,Milton H. Saier,Robert E. W. Hancock,Stephen Lory,Maynard V. Olson +31 more
TL;DR: It is proposed that the size and complexity of the P. aeruginosa genome reflect an evolutionary adaptation permitting it to thrive in diverse environments and resist the effects of a variety of antimicrobial substances.
Journal ArticleDOI
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
Timothy J. Ley,Christopher A. Miller,Li Ding,Benjamin J. Raphael,Andrew J. Mungall,Gordon Robertson,Katherine A. Hoadley,Timothy J. Triche,Peter W. Laird,Jack Baty,Lucinda Fulton,Robert S. Fulton,Sharon Heath,Joelle Kalicki-Veizer,Cyriac Kandoth,Jeffery M. Klco,Daniel C. Koboldt,Krishna L. Kanchi,Shashikant Kulkarni,Tamara Lamprecht,David E. Larson,G. Lin,Charles Lu,Michael D. McLellan,Joshua F. McMichael,Jacqueline E. Payton,Heather Schmidt,David H. Spencer,Michael H. Tomasson,John W. Wallis,Lukas D. Wartman,Mark A. Watson,John S. Welch,Michael C. Wendl,Adrian Ally,Miruna Balasundaram,Inanc Birol,Yaron S.N. Butterfield,Readman Chiu,Andy Chu,Eric Chuah,Hye Jung E. Chun,Richard Corbett,Noreen Dhalla,Ranabir Guin,An He,Carrie Hirst,Martin Hirst,Robert A. Holt,Steven J.M. Jones,Aly Karsan,Darlene Lee,Haiyan I. Li,Marco A. Marra,Michael Mayo,Richard A. Moore,Karen Mungall,Jeremy Parker,Erin Pleasance,Patrick Plettner,Jacquie Schein,Dominik Stoll,Lucas Swanson,Angela Tam,Nina Thiessen,Richard Varhol,Natasja Wye,Yongjun Zhao,Stacey Gabriel,Gad Getz,Carrie Sougnez,Lihua Zou,Mark D.M. Leiserson,Fabio Vandin,Hsin-Ta Wu,Frederick Applebaum,Stephen B. Baylin,Rehan Akbani,Bradley M. Broom,Ken Chen,Thomas C. Motter,Khanh Thi-Thuy Nguyen,John N. Weinstein,Nianziang Zhang,Martin L. Ferguson,Christopher Adams,Aaron D. Black,Jay Bowen,Julie M. Gastier-Foster,Thomas Grossman,Tara M. Lichtenberg,Lisa Wise,Tanja Davidsen,John A. Demchok,Kenna R. Mills Shaw,Margi Sheth,Heidi J. Sofia,Liming Yang,James R. Downing,Greg Eley,Shelley Alonso,Brenda Ayala,Julien Baboud,Mark Backus,Sean P. Barletta,Dominique L. Berton,Anna L. Chu,Stanley Girshik,Mark A. Jensen,Ari B. Kahn,Prachi Kothiyal,Matthew C. Nicholls,Todd Pihl,David Pot,Rohini Raman,Rashmi N. Sanbhadti,Eric E. Snyder,Deepak Srinivasan,Jessica Walton,Yunhu Wan,Zhining Wang,Jean Pierre J. Issa,Michelle M. Le Beau,Martin Carroll,Hagop M. Kantarjian,Steven M. Kornblau,Moiz S. Bootwalla,Phillip H. Lai,Hui Shen,David Van Den Berg,Daniel J. Weisenberger,Daniel C. Link,Matthew J. Walter,Bradley A. Ozenberger,Elaine R. Mardis,Peter Westervelt,Timothy A. Graubert,John F. DiPersio,Richard K. Wilson +138 more
TL;DR: It is found that a complex interplay of genetic events contributes to AML pathogenesis in individual patients and the databases from this study are widely available to serve as a foundation for further investigations of AMl pathogenesis, classification, and risk stratification.
Journal ArticleDOI
Comprehensive transposon mutant library of Pseudomonas aeruginosa.
Michael A. Jacobs,Ashley Alwood,Iyarit Thaipisuttikul,David H. Spencer,Eric Haugen,Stephen Ernst,Oliver Will,Rajinder Kaul,Christopher K. Raymond,Ruth Levy,Liu Chun-Rong,Donald Guenthner,Donald Bovee,Maynard V. Olson,Colin Manoil +14 more
TL;DR: P phenotypic analysis of the collection may produce essentially complete lists of genes required for diverse biological activities, as well as facilitate downstream studies of gene expression, protein localization, epistasis, and chromosome engineering.
Journal ArticleDOI
CIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer
Malachi Griffith,Nicholas C. Spies,Kilannin Krysiak,Joshua F. McMichael,Adam C. Coffman,Arpad Danos,Benjamin J. Ainscough,Cody Ramirez,Damian T. Rieke,Lynzey Kujan,Erica K. Barnell,Alex H. Wagner,Zachary L. Skidmore,Amber Z. Wollam,Connor J. Liu,Martin R. Jones,Rachel L. Bilski,Robert Lesurf,Yan Yang Feng,Nakul M. Shah,Melika Bonakdar,Lee Trani,Matthew K. Matlock,Avinash Ramu,Katie M. Campbell,Gregory C. Spies,Aaron P. Graubert,Karthik Gangavarapu,James M. Eldred,David E. Larson,Jason Walker,Benjamin M. Good,Chunlei Wu,Andrew I. Su,Rodrigo Dienstmann,Adam A. Margolin,David Tamborero,Nuria Lopez-Bigas,Steven J.M. Jones,Ron Bose,David H. Spencer,Lukas D. Wartman,Richard K. Wilson,Elaine R. Mardis,Obi L. Griffith +44 more
TL;DR: CIViC is an expert-crowdsourced knowledgebase for Clinical Interpretation of Variants in Cancer describing the therapeutic, prognostic, diagnostic and predisposing relevance of inherited and somatic variants of all types.
Journal ArticleDOI
The R882H DNMT3A Mutation Associated with AML Dominantly Inhibits Wild-Type DNMT3A by Blocking Its Ability to Form Active Tetramers
David A. Russler-Germain,David H. Spencer,Margaret A. Young,Tamara Lamprecht,Christopher A. Miller,Robert S. Fulton,Matthew R. Meyer,Petra Erdmann-Gilmore,Raymond R. Townsend,Richard K. Wilson,Timothy J. Ley +10 more
TL;DR: AML cells with the R882H mutation have severely reduced de novo methyltransferase activity and focal hypomethylation at specific CpGs throughout AML cell genomes.