Charles K. Stover

TL;DR: It is proposed that the size and complexity of the P. aeruginosa genome reflect an evolutionary adaptation permitting it to thrive in diverse environments and resist the effects of a variety of antimicrobial substances.

TL;DR: Extrachromosomal and integrative expression vectors carrying the regulatory sequences for major BCG heat-shock proteins have been developed and can elicit long-lasting humoral and cellular immune responses to foreign antigens in mice.

TL;DR: The live attenuated bacillus Calmette-Guerin (BCG) vaccine for the prevention of disease associated with mycobacterium tuberculosis was derived from the closely related virulent tubercle bacilli, Mycobacteriaium bovis, and the precise junctions and DNA sequence of each deletion were determined as discussed by the authors.

TL;DR: Improved antibody responses were observed in heterogeneous mouse strains that vary in their immune responsiveness to OspA and sensitivity to BCG growth, and expression of protective antigens as chimeric membrane-associated lipoproteins on recombinant BCG may result in the generation of new candidate vaccines against Lyme borreliosis and other human or veterinary diseases where humoral immunity is the protective response.

TL;DR: Signature‐tag transposon mutagenesis screening of a 1520‐member library identified numerous S. aureus genetic loci affecting growth and survival in four complementary animal infection models, providing insight into the complexities of human infection and on the molecular mechanisms that could be targeted by new antibacterial therapies.