A
Arthur Friedman
Researcher at United States Military Academy
Publications - 17
Citations - 4819
Arthur Friedman is an academic researcher from United States Military Academy. The author has contributed to research in topics: DNA vaccination & Virus. The author has an hindex of 16, co-authored 17 publications receiving 4766 citations. Previous affiliations of Arthur Friedman include Merck & Co..
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Journal ArticleDOI
Heterologous protection against influenza by injection of DNA encoding a viral protein
Jeffrey B. Ulmer,John J. Donnelly,Suezanne E. Parker,Gary Rhodes,Philip L. Felgner,V. J. Dwarki,Stanislaw H. Gromkowski,R. Randall Deck,Corrille M. DeWitt,Arthur Friedman,Linda A. Hawe,Karen R. Leander,Douglas Martinez,Helen C. Perry,John W. Shiver,Donna L. Montgomery,Margaret A. Liu +16 more
TL;DR: To generate a viral antigen for presentation to the immune system without the limitations of direct peptide delivery or viral vectors, plasmid DNA encoding influenza A nucleop protein was injected into the quadriceps of BALB/c mice and resulted in the generation of nucleoprotein-specific CTLs.
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Preclinical efficacy of a prototype DNA vaccine: Enhanced protection against antigenic drift in influenza virus
John J. Donnelly,Arthur Friedman,Douglas Martinez,Donna L. Montgomery,John W. Shiver,Sherri L. Motzel,Jeffrey B. Ulmer,Margaret A. Liu +7 more
TL;DR: It is demonstrated that DNA vaccines may be more effective, particularly against different strains of virus, than inactivated virus or subvirion vaccines.
Journal ArticleDOI
Heterologous and Homologous Protection Against Influenza A by DNA Vaccination: Optimization of DNA Vectors
Donna L. Montgomery,John W. Shiver,Karen R. Leander,Helen C. Perry,Arthur Friedman,Douglas Martinez,Jeffrey B. Ulmer,John J. Donnelly,Margaret A. Liu +8 more
TL;DR: Immunization of mice with the NP and HA expression vectors resulted in protection from subsequent lethal challenges of influenza using either heterologous or homologous strains, respectively.
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Priming of cytotoxic T lymphocytes by DNA vaccines: requirement for professional antigen presenting cells and evidence for antigen transfer from myocytes.
Tong-Ming Fu,Jeffrey B. Ulmer,Michael J. Caulfield,R. Randall Deck,Arthur Friedman,Su Wang,Xu Liu,John J. Donnelly,Margaret A. Liu +8 more
TL;DR: Investigating the role of muscle cells and involvement of professional antigen-presenting cells (APCs) in priming CTL responses following DNA vaccination found expression of antigen by muscle cells in BM chimeric mice after myoblast transplantation is sufficient to induce CTL restricted only by the MHC haplotype of the donor BM, indicating that transfer of antigen from myocytes to professional APCs can occur.
Journal ArticleDOI
Protective cd4+ and cd8+ t cells against influenza virus induced by vaccination with nucleoprotein dna
Jeffrey B. Ulmer,Tong-Ming Fu,R. Randall Deck,Arthur Friedman,Liming Guan,Corrille M. DeWitt,Xu Liu,Su Wang,Margaret A. Liu,John J. Donnelly,Michael J. Caulfield +10 more
TL;DR: The present study characterized in more detail the cellular immune responses induced by NP DNA, which included robust lymphoproliferation and Th1-type cytokine secretion in response to antigen-specific restimulation of splenocytes in vitro.