L
Linda A. Hawe
Researcher at United States Military Academy
Publications - 4
Citations - 2751
Linda A. Hawe is an academic researcher from United States Military Academy. The author has contributed to research in topics: Antigen & Antigen processing. The author has an hindex of 4, co-authored 4 publications receiving 2716 citations. Previous affiliations of Linda A. Hawe include Merck & Co..
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Journal ArticleDOI
Heterologous protection against influenza by injection of DNA encoding a viral protein
Jeffrey B. Ulmer,John J. Donnelly,Suezanne E. Parker,Gary Rhodes,Philip L. Felgner,V. J. Dwarki,Stanislaw H. Gromkowski,R. Randall Deck,Corrille M. DeWitt,Arthur Friedman,Linda A. Hawe,Karen R. Leander,Douglas Martinez,Helen C. Perry,John W. Shiver,Donna L. Montgomery,Margaret A. Liu +16 more
TL;DR: To generate a viral antigen for presentation to the immune system without the limitations of direct peptide delivery or viral vectors, plasmid DNA encoding influenza A nucleop protein was injected into the quadriceps of BALB/c mice and resulted in the generation of nucleoprotein-specific CTLs.
Journal ArticleDOI
Targeted delivery of peptide epitopes to class I major histocompatibility molecules by a modified Pseudomonas exotoxin.
John J. Donnelly,Jeffrey B. Ulmer,Linda A. Hawe,Arthur Friedman,Xiao-Ping Shi,Karen R. Leander,John W. Shiver,Oliff Allen I,Douglas Martinez,Donna L. Montgomery +9 more
TL;DR: Fusion of peptide or polypeptide epitopes with PE provides a potential means of eliciting CTLs without the use of self-replicating agents, as well as a useful probe for studying MHC class I-restricted antigen processing.
Journal ArticleDOI
A vaccine carrier derived from Neisseria meningitidis with mitogenic activity for lymphocytes.
Margaret A. Liu,Arthur Friedman,Oliff Allen I,Tai Joseph Y,Douglas Martinez,R. Randall Deck,Joseph T. Shieh,Timothy D. Jenkins,John J. Donnelly,Linda A. Hawe +9 more
TL;DR: This mitogenic activity appears to date to be unique to this carrier protein of the carrier proteins tested and may contribute to the ability of the H. influenzae type b conjugate vaccine made with the outer membrane protein complex to generate IgG anti-polysaccharide antibody responses in mice and infant monkeys and protective immune responses in infants less than 6 months of age.
Patent
Recombinant DNA sequences and plasmids for cellular immunity vaccines from bacterial toxinantigen conjugates
John J. Donnelly,Liu Margaret A,Arthur Friedman,Mark S. Marshall,Linda A. Hawe,Donna L. Montgomery,Oliff Allen I,Xiao-Ping Shi,Jeffrey Ulmer +8 more
TL;DR: In this article, a modified bacterial toxin that has translocating ability and a polypeptide or protein that is exogenous to an antigen-presenting cell was used to elicit an immune response by cytotoxic T lymphocytes.