D
Donna L. Montgomery
Researcher at Merck & Co.
Publications - 66
Citations - 6556
Donna L. Montgomery is an academic researcher from Merck & Co.. The author has contributed to research in topics: Antigen & DNA vaccination. The author has an hindex of 31, co-authored 66 publications receiving 6471 citations. Previous affiliations of Donna L. Montgomery include United States Military Academy & University of Kent.
Papers
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Journal ArticleDOI
Heterologous protection against influenza by injection of DNA encoding a viral protein
Jeffrey B. Ulmer,John J. Donnelly,Suezanne E. Parker,Gary Rhodes,Philip L. Felgner,V. J. Dwarki,Stanislaw H. Gromkowski,R. Randall Deck,Corrille M. DeWitt,Arthur Friedman,Linda A. Hawe,Karen R. Leander,Douglas Martinez,Helen C. Perry,John W. Shiver,Donna L. Montgomery,Margaret A. Liu +16 more
TL;DR: To generate a viral antigen for presentation to the immune system without the limitations of direct peptide delivery or viral vectors, plasmid DNA encoding influenza A nucleop protein was injected into the quadriceps of BALB/c mice and resulted in the generation of nucleoprotein-specific CTLs.
Journal ArticleDOI
Immunogenicity and protective efficacy of a tuberculosis DNA vaccine
Kris Huygen,Olivier Denis,Donna L. Montgomery,Yawman Am,Deck Rr,DeWitt Cm,Ian M. Orme,Baldwin S,C.D. D'Souza,Annie Drowart,E Lozes,Paul Vandenbussche,Van Vooren Jp,Liu Margaret A,Jeffrey B. Ulmer +14 more
TL;DR: Results indicate that immunization with DNA encoding a mycobacterial antigen provides an efficient and simple method for generating protective immunity and that this technique may be useful for defining the protective antigens of M. tuberculosis, leading to the development of a more effective vaccine.
Journal ArticleDOI
Preclinical efficacy of a prototype DNA vaccine: Enhanced protection against antigenic drift in influenza virus
John J. Donnelly,Arthur Friedman,Douglas Martinez,Donna L. Montgomery,John W. Shiver,Sherri L. Motzel,Jeffrey B. Ulmer,Margaret A. Liu +7 more
TL;DR: It is demonstrated that DNA vaccines may be more effective, particularly against different strains of virus, than inactivated virus or subvirion vaccines.
Journal ArticleDOI
Heterologous and Homologous Protection Against Influenza A by DNA Vaccination: Optimization of DNA Vectors
Donna L. Montgomery,John W. Shiver,Karen R. Leander,Helen C. Perry,Arthur Friedman,Douglas Martinez,Jeffrey B. Ulmer,John J. Donnelly,Margaret A. Liu +8 more
TL;DR: Immunization of mice with the NP and HA expression vectors resulted in protection from subsequent lethal challenges of influenza using either heterologous or homologous strains, respectively.
Patent
Polynucleotide tuberculosis vaccine
TL;DR: In this paper, polynucleotide vaccines were used to immunize mice against Mycobacterium tuberculosis (M.tb) antigens in the spleens and lungs.