S
Stanislaw H. Gromkowski
Publications - 6
Citations - 3187
Stanislaw H. Gromkowski is an academic researcher. The author has contributed to research in topics: Plasmid & Virus. The author has an hindex of 6, co-authored 6 publications receiving 3146 citations.
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Heterologous protection against influenza by injection of DNA encoding a viral protein
Jeffrey B. Ulmer,John J. Donnelly,Suezanne E. Parker,Gary Rhodes,Philip L. Felgner,V. J. Dwarki,Stanislaw H. Gromkowski,R. Randall Deck,Corrille M. DeWitt,Arthur Friedman,Linda A. Hawe,Karen R. Leander,Douglas Martinez,Helen C. Perry,John W. Shiver,Donna L. Montgomery,Margaret A. Liu +16 more
TL;DR: To generate a viral antigen for presentation to the immune system without the limitations of direct peptide delivery or viral vectors, plasmid DNA encoding influenza A nucleop protein was injected into the quadriceps of BALB/c mice and resulted in the generation of nucleoprotein-specific CTLs.
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Cancer gene therapy using plasmid DNA: pharmacokinetic study of DNA following injection in mice.
Denise Lew,Suezanne E. Parker,Terrie Latimer,Anna M. Abai,Ann Kuwahara-Rundell,S G Doh,Zhi Yong Yang,Drake Laface,Stanislaw H. Gromkowski,Gary J. Nabel,Marston Manthorpe,Jon Norman +11 more
TL;DR: Blood half-life and tissue distribution of plasmid DNA and potential expression in tissues were examined and it was demonstrated that intact DNA was differentially retained in the lung, spleen, liver, heart, kidney, marrow, and muscle up to 24 hr postinjection.
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Long-Term Anti-Nucleoprotein Cellular and Humoral Immunity Is Induced by Intramuscular Injection of Plasmid DNA Containing NP Gene
Michelle A. Yankauckas,Jane E. Morrow,Suezanne E. Parker,Anna M. Abai,Gary Rhodes,Dwarki Varavani J,Stanislaw H. Gromkowski +6 more
TL;DR: It is shown that a single intramuscular injection of a small dose of nucleoprotein plasmid DNA generates nucleop protein-specific cellular and humoral immune responses that last 1 year that are associated with the CD8+ subpopulation of T cells.
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Cancer gene therapy using plasmid DNA: safety evaluation in rodents and non-human primates
S E Parker,H.L. Vahlsing,L M Serfilippi,Craig L. Franklin,S G Doh,Stanislaw H. Gromkowski,Denise Lew,Marston Manthorpe,Jon Norman +8 more
TL;DR: The results suggest that the direct transfer of VCL-1005, a plasmid DNA-lipid complex, could be used for the safe in vivo delivery of recombinant DNA for a cancer gene therapy trial.
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Immunization with plasmid DNA using a pneumatic gun.
TL;DR: A method by which the Med-E-Jet pneumatic vaccination gun can be used to propel intact, supercoiled plasmid DNA through skin and into skeletal muscles of mice would be well-suited for genetic immunization of humans.