Arun K. Tiwari

TL;DR: There has been considerable progress reaffirming previous findings and discovery of novel genetic factors in pharmacogenetics of antipsychotic-induced weight gain, and new evidence suggests that the DRD2, TNF, SNAP-25 and MC4R genes are also prominent risk factors.

TL;DR: These data implicate MC4R in extreme SGA-induced weight gain and related metabolic disturbances, and could lead to alternative treatment strategies in this population of patients undergoing first exposure to antipsychotic drugs.

TL;DR: The findings suggest that MIR137 substantially influences variation in phenotypes that are thought to have an important role in clinical outcome and treatment response and the possible consequences of genetic risk factors may be distinct in patients with schizophrenia compared with healthy controls.

TL;DR: An updated meta-analysis of nine previous studies plus the current sample suggest that the -759C allele is associated with antipsychotic-induced weight gain.

TL;DR: Evidence is provided that the CNR1 gene may be associated with antipsychotic-induced weight gain in chronic schizophrenia patients and electrophoretic mobility shift assays showed that the presence of the T allele created a binding site for arylhydrocarbon receptor translocator (ARNT), a member of the basic helix–loop–helix/Per–Arnt–Sim protein family.