Daniel Felsky

TL;DR: The systematic profiling of the dorsolateral prefrontal cortex obtained from a subset of autopsied individuals enrolled in the Religious Orders Study or the Rush Memory and Aging Project, which are jointly designed prospective studies of aging and dementia with detailed, longitudinal cognitive phenotyping during life and a quantitative, structured neuropathologic examination after death, is initiated.

TL;DR: A colocalization analysis is applied to identify genes underlying the GWAS association peaks for schizophrenia and identify a potentially novel gene colocalized with lncRNA RP11-677M14.

TL;DR: White matter tract disruption as a neurobiological feature of the deficit syndrome and reductions in cortical thickness as a common feature of patients with a diagnosis of schizophrenia are demonstrated.

TL;DR: The novel findings provide convergent evidence in vivo for a BDNF genetic mechanism of susceptibility in an intermediate phenotype related to AD by examining cortical thickness, fractional anisotropy of white matter tracts, and episodic memory performance.

TL;DR: The findings suggest that MIR137 substantially influences variation in phenotypes that are thought to have an important role in clinical outcome and treatment response and the possible consequences of genetic risk factors may be distinct in patients with schizophrenia compared with healthy controls.