A common polymorphism in the cannabinoid receptor 1 (CNR1) gene is associated with antipsychotic-induced weight gain in Schizophrenia.
Arun K. Tiwari,Clement C. Zai,Olga Likhodi,Annika Lisker,Deepika Singh,Renan P. Souza,Poonam Batra,Syed H.E. Zaidi,Sheng Chen,Fang Liu,Imke Puls,Herbert Y. Meltzer,Jeffrey A. Lieberman,James L. Kennedy,Daniel J. Müller,Daniel J. Müller +15 more
TLDR
Evidence is provided that the CNR1 gene may be associated with antipsychotic-induced weight gain in chronic schizophrenia patients and electrophoretic mobility shift assays showed that the presence of the T allele created a binding site for arylhydrocarbon receptor translocator (ARNT), a member of the basic helix–loop–helix/Per–Arnt–Sim protein family.About:
This article is published in Neuropsychopharmacology.The article was published on 2010-01-27 and is currently open access. It has received 97 citations till now. The article focuses on the topics: Atypical antipsychotic & Weight gain.read more
Citations
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Journal ArticleDOI
Antipsychotic drugs and obesity
TL;DR: Sophisticated molecular studies and genome-wide association studies, ideally in antipsychotic-naïve/first episode samples, are needed to further advance the field.
Journal ArticleDOI
Pharmacogenetics of antipsychotic-induced weight gain: review and clinical implications
Tristram A. Lett,T J M Wallace,Nabilah I. Chowdhury,Arun K. Tiwari,James L. Kennedy,Daniel J. Müller +5 more
TL;DR: There has been considerable progress reaffirming previous findings and discovery of novel genetic factors in pharmacogenetics of antipsychotic-induced weight gain, and new evidence suggests that the DRD2, TNF, SNAP-25 and MC4R genes are also prominent risk factors.
Journal ArticleDOI
Association Between Common Variants Near the Melanocortin 4 Receptor Gene and Severe Antipsychotic Drug–Induced Weight Gain
Anil K. Malhotra,Christoph U. Correll,Nabilah I. Chowdhury,Daniel J. Müller,Peter K. Gregersen,Annette Lee,Arun K. Tiwari,John M. Kane,W. Wolfgang Fleischhacker,René S. Kahn,Roel A. Ophoff,Jeffrey A. Lieberman,Herbert Y. Meltzer,Todd Lencz,James L. Kennedy +14 more
TL;DR: These data implicate MC4R in extreme SGA-induced weight gain and related metabolic disturbances, and could lead to alternative treatment strategies in this population of patients undergoing first exposure to antipsychotic drugs.
Journal ArticleDOI
Contributions of endocannabinoid signaling to psychiatric disorders in humans: Genetic and biochemical evidence
TL;DR: The hypothesis that endocannabinoid signaling could be dysfunctional in a number of mental disorders is suggested and further studies are encouraged to encourage further studies in this very interesting and important area.
Journal ArticleDOI
Pharmacogenetic Associations of Antipsychotic Drug-Related Weight Gain: A Systematic Review and Meta-analysis
Jian-Ping Zhang,Todd Lencz,Ryan X. Zhang,Masahiro Nitta,Lawrence Maayan,Majnu John,Majnu John,Delbert Robinson,W. Wolfgang Fleischhacker,René S. Kahn,Roel A. Ophoff,John M. Kane,Anil K. Malhotra,Christoph U. Correll +13 more
TL;DR: In conclusion, antipsychotic-related weight gain is polygenic and associated with specific genetic variants, especially in genes coding for antipsychotics pharmacodynamic targets.
References
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Haploview: analysis and visualization of LD and haplotype maps
TL;DR: Haploview is a software package that provides computation of linkage disequilibrium statistics and population haplotype patterns from primary genotype data in a visually appealing and interactive interface.
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A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies
TL;DR: The procedure reported here is the most economical, safe and rapid for preparation of DNA from whole blood and eliminates completely the use of proteinase K treatment.
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Leptin-regulated endocannabinoids are involved in maintaining food intake
Vincenzo Di Marzo,Sravan K. Goparaju,Lei Wang,Lei Wang,Jie Liu,Jie Liu,Sandor Batkai,Sandor Batkai,Zoltán Járai,Filomena Fezza,Grant I. Miura,Richard D. Palmiter,Takayuki Sugiura,George Kunos,George Kunos +14 more
TL;DR: It is shown that following temporary food restriction, CB1 receptor knockout mice eat less than their wild-type littermates, and the CB1 antagonist SR141716A reduces food intake in wild- type but not knockout mice, which indicates that endocannabinoids in the hypothalamus may tonically activate CB1 receptors to maintain food intake and form part of the neural circuitry regulated by leptin.
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Pedigree disequilibrium tests for multilocus haplotypes.
TL;DR: A permutation procedure for the null hypothesis of interest is described, which controls for violation of the assumptions, and a likelihood‐ratio test is proposed, using the expectation‐maximization (E‐M) algorithm to account for haplotype ambiguities.
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The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis
Daniela Cota,Giovanni Marsicano,Matthias H. Tschöp,Yvonne Grübler,Cornelia Flachskamm,M. I. Schubert,Dorothee P. Auer,Alexander Yassouridis,Christa Thöne-Reineke,Sylvia Ortmann,Federica Tomassoni,Cristina Cervino,Enzo Nisoli,Astrid C E Linthorst,Renato Pasquali,Beat Lutz,Günter K. Stalla,Uberto Pagotto +17 more
TL;DR: It is shown that the lack of CB1 in mice with a disrupted CB1 gene causes hypophagia and leanness, and the cannabinoid system is an essential endogenous regulator of energy homeostasis via central orexigenic as well as peripheral lipogenic mechanisms and might therefore represent a promising target to treat diseases characterized by impaired energy balance.