Åse Mattsson

TL;DR: Human A549 lung epithelial cells were challenged with 18O-labeled hydrogen peroxide and showed slow turnover rates of adducts in RNA and DNA, where guanine in RNA was 14–25 times more common than in DNA.

TL;DR: How future risk assessment strategies for complex PAH mixtures should be based around whole mixture assessment in order to account for interaction effects is discussed, and the commonly used biological end-point of DNA damage formation is shown to be insufficient for studying mixture effects.

TL;DR: It is shown that liver-specific co-disruption of the genes encoding Trx1, TrxR1, and Gsr (triple-null) causes dramatic hepatocyte hyperproliferation, and even in the absence of Trx 1, methionine-fueled glutathione production supports hepatocyte S phase deoxyribonucleotide production.

TL;DR: In this article, the authors compared the effects of polycyclic aromatic hydrocarbons (PAHs) extracts from contaminated soils collected at six industrial settings in Sweden and found that most soil extracts induced phosphorylation of Mdm2 at the 2A10 epitope at low concentrations.

TL;DR: It is concluded that the in vitro based approach for establishing MPFs could be a novel method to assess whole mixture samples of airborne PAHs to improve health risk assessment.