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Edyta Bajak
Researcher at Karolinska Institutet
Publications - 7
Citations - 374
Edyta Bajak is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: DNA & Gene. The author has an hindex of 7, co-authored 7 publications receiving 343 citations. Previous affiliations of Edyta Bajak include Uppsala University.
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Journal ArticleDOI
Hydrogen peroxide causes greater oxidation in cellular RNA than in DNA
TL;DR: Human A549 lung epithelial cells were challenged with 18O-labeled hydrogen peroxide and showed slow turnover rates of adducts in RNA and DNA, where guanine in RNA was 14–25 times more common than in DNA.
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Genomic analysis suggests higher susceptibility of children to air pollution
Danitsja M. van Leeuwen,Marie Pedersen,Peter J. M. Hendriksen,André Boorsma,Marcel H. M. van Herwijnen,Ralph W.H. Gottschalk,Micheline Kirsch-Volders,Lisbeth E. Knudsen,Radim J. Sram,Edyta Bajak,Joost H.M. van Delft,Jos C. S. Kleinjans +11 more
TL;DR: Differences between children and adults in relation to air pollution exposure at the transcriptome level are suggested and underline the necessity of implementing environmental health policy measures specifically for protecting children's health.
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Genome-wide differential gene expression in children exposed to air pollution in the Czech Republic.
D.M. van Leeuwen,M.H.M. van Herwijnen,Marie Pedersen,Lisbeth E. Knudsen,Micheline Kirsch-Volders,Radim J. Sram,Yvonne C.M. Staal,Edyta Bajak,J.H.M. van Delft,Jos C. S. Kleinjans +9 more
TL;DR: It is suggested that transcriptomic analysis represents a promising biomarker for environmental carcinogenesis, as an effect of air pollution on the primary structural unit of the condensed DNA.
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H2AX phosphorylation in A549 cells induced by the bulky and stable DNA adducts of benzo[a]pyrene and dibenzo[a,l]pyrene diol epoxides.
TL;DR: The extent of H2AXgamma formation and persistence was related to both the number of adducts and their structural features, and correlated with the previously observed kinetics of elimination of BPDE and DBPDEAdducts.
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Protein S-glutathionylation correlates to selective stress gene expression and cytoprotection
TL;DR: The induction of the chaperone responses at the level of mRNA was clearly shown to translate into a more resistant morphological phenotype in response to both heat shock and oxidative stress induced by the DNA-damaging pro-oxidant potassium bromate.