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Ashwati Vipin
Researcher at National University of Singapore
Publications - 23
Citations - 311
Ashwati Vipin is an academic researcher from National University of Singapore. The author has contributed to research in topics: Medicine & Grey matter. The author has an hindex of 8, co-authored 16 publications receiving 214 citations.
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Journal ArticleDOI
Neurovascular coupling: in vivo optical techniques for functional brain imaging
Lun-De Liao,Vassiliy Tsytsarev,Ignacio Delgado-Martinez,Meng-Lin Li,Reha S. Erzurumlu,Ashwati Vipin,Josue Orellana,Yan-Ren Lin,Hsin Yi Lai,You Yin Chen,Nitish V. Thakor,Nitish V. Thakor +11 more
TL;DR: An overview of the current optical approaches used for the in vivo imaging of neurovascular coupling events in small animal models is presented and a glimpse of the possible ways in which these techniques might be translated to human studies for clinical investigations of pathophysiology and disease is provided.
Journal ArticleDOI
Higher Peripheral TREM2 mRNA Levels Relate to Cognitive Deficits and Hippocampal Atrophy in Alzheimer's Disease and Amnestic Mild Cognitive Impairment.
Yi Jayne Tan,Yi Jayne Tan,Adeline S.L. Ng,Ashwati Vipin,Joseph Lim,Russell J. Chander,Fang Ji,Yingwei Qiu,Simon Kang Seng Ting,Shahul Hameed,Tih-Shih Lee,Li Zeng,Nagaendran Kandiah,Juan Zhou,Juan Zhou +14 more
TL;DR: Peripheral TREM2 mRNA levels are higher in AD and are associated with AD-related cognitive deficits and hippocampal atrophy, suggesting that TREM 2 may be a potential non-invasive peripheral biomarker for AD diagnosis.
Journal ArticleDOI
Cerebrovascular disease influences functional and structural network connectivity in patients with amnestic mild cognitive impairment and Alzheimer’s disease
Ashwati Vipin,Yng Miin Loke,Siwei Liu,Saima Hilal,Saima Hilal,Hee Youn Shim,Xin Xu,Xin Xu,Boon Yeow Tan,Narayanaswamy Venketasubramanian,Christopher Chen,Christopher Chen,Juan Zhou,Juan Zhou +13 more
TL;DR: Divergent DMN and ECN functional connectivity changes in CeVD and non-CeVD subjects are demonstrated through diverging and deleterious network-based degeneration underlying domain-specific cognitive impairment.
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Amyloid burden accelerates white matter degradation in cognitively normal elderly individuals.
Ashwati Vipin,Kwun Kei Ng,Fang Ji,Hee Youn Shim,Joseph Lim,Ofer Pasternak,Juan Helen Zhou,Juan Helen Zhou +7 more
TL;DR: This is the first study to illustrate the influence of Aβ burden on early longitudinal (in addition to baseline) white matter changes in cognitively normal elderly individuals at‐risk of Alzheimer's disease, underscoring the importance of longitudinal studies in assessing microstructural alterations in individuals at risk of Alzheimer’s disease prior to symptoms onset.
Journal ArticleDOI
Regional White Matter Hyperintensity Influences Grey Matter Atrophy in Mild Cognitive Impairment
Ashwati Vipin,Heidi Jing Ling Foo,Joseph Lim,Russell J. Chander,Ting Ting Yong,Adeline Su Lyn Ng,Shahul Hameed,Simon Kang Seng Ting,Juan Zhou,Juan Zhou,Nagaendran Kandiah +10 more
TL;DR: Although WMH volume was highest in AD subjects, it had a more pervasive influence on brain structure and cognitive impairment in MCI, highlighting the importance of early detection of cerebrovascular disease, as its intervention at the MCI stage might potentially slow down neurodegeneration.