Ashwati Vipin

TL;DR: An overview of the current optical approaches used for the in vivo imaging of neurovascular coupling events in small animal models is presented and a glimpse of the possible ways in which these techniques might be translated to human studies for clinical investigations of pathophysiology and disease is provided.

TL;DR: Peripheral TREM2 mRNA levels are higher in AD and are associated with AD-related cognitive deficits and hippocampal atrophy, suggesting that TREM 2 may be a potential non-invasive peripheral biomarker for AD diagnosis.

TL;DR: Divergent DMN and ECN functional connectivity changes in CeVD and non-CeVD subjects are demonstrated through diverging and deleterious network-based degeneration underlying domain-specific cognitive impairment.

TL;DR: This is the first study to illustrate the influence of Aβ burden on early longitudinal (in addition to baseline) white matter changes in cognitively normal elderly individuals at‐risk of Alzheimer's disease, underscoring the importance of longitudinal studies in assessing microstructural alterations in individuals at risk of Alzheimer’s disease prior to symptoms onset.

TL;DR: Although WMH volume was highest in AD subjects, it had a more pervasive influence on brain structure and cognitive impairment in MCI, highlighting the importance of early detection of cerebrovascular disease, as its intervention at the MCI stage might potentially slow down neurodegeneration.