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Astrid Weins
Researcher at Brigham and Women's Hospital
Publications - 62
Citations - 2808
Astrid Weins is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Kidney disease & Podocyte. The author has an hindex of 23, co-authored 51 publications receiving 2091 citations. Previous affiliations of Astrid Weins include Albert Einstein College of Medicine & Hammersmith Hospital.
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Journal ArticleDOI
Abatacept in B7-1–Positive Proteinuric Kidney Disease
Chih Chuan Yu,Chih Chuan Yu,Alessia Fornoni,Astrid Weins,Samy Hakroush,Dony Maiguel,Junichiro Sageshima,Linda Chen,Gaetano Ciancio,Mohd Hafeez Faridi,Daniel Behr,Kirk N. Campbell,Jer Ming Chang,Hung Chun Chen,Jun Oh,Christian Faul,M. Amin Arnaout,Paolo Fiorina,Vineet Gupta,Anna Greka,George W. Burke,Peter Mundel +21 more
TL;DR: Data indicate that abatacept may stabilize β1-integrin activation in podocytes and reduce proteinuria in patients with B7-1-positive glomerular disease.
Journal ArticleDOI
Direct dynamin–actin interactions regulate the actin cytoskeleton
Changkyu Gu,Suma Yaddanapudi,Astrid Weins,Teresia Osborn,Jochen Reiser,Martin R. Pollak,John H. Hartwig,Sanja Sever +7 more
TL;DR: The results support a model in which assembled dynamin, generated through interactions with short actin filaments, promotes actin polymerization via displacement of actin‐CPs.
Journal ArticleDOI
Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53.
Kyoung Wan Yoon,Sanguine Byun,Eunjeong Kwon,So Young Hwang,Kiki Chu,Masatsugu Hiraki,Seung-Hee Jo,Astrid Weins,Samy Hakroush,Angelika Cebulla,David B. Sykes,Anna Greka,Peter Mundel,David E. Fisher,Anna Mandinova,Anna Mandinova,Sam W. Lee,Sam W. Lee +17 more
TL;DR: A postapoptotic target gene of p53, Death Domain1α (DD1α), is identified that is responsive to genotoxic stresses and expressed in immune cells and appears to function as an immunoregulator of T cell tolerance.
Journal ArticleDOI
Mutational and Biological Analysis of alpha-actinin-4 in focal segmental glomerulosclerosis.
Astrid Weins,Peter Kenlan,Stephanie Herbert,Tu Cam Le,Ivan Villegas,Bernard S. Kaplan,Gerald B. Appel,Martin R. Pollak +7 more
TL;DR: Five ACTN4 mutations that are believed to be disease causing as well as a number of variants with unclear contribution to disease now have been identified and the possibility that some of these other variants increase the susceptibility to FSGS cannot be excluded.
Journal ArticleDOI
Nanoscale imaging of clinical specimens using pathology-optimized expansion microscopy
Yongxin Zhao,Octavian Bucur,Humayun Irshad,Humayun Irshad,Humayun Irshad,Fei Chen,Astrid Weins,Andreea Lucia Stancu,Andreea Lucia Stancu,Eun-Young Oh,Marcello DiStasio,Vanda F. Torous,Benjamin Glass,Isaac E. Stillman,Stuart J. Schnitt,Andrew H. Beck,Andrew H. Beck,Andrew H. Beck,Edward S. Boyden +18 more
TL;DR: A clinically optimized form of ExM that supports nanoscale imaging of human tissue specimens that have been fixed with formalin, embedded in paraffin, stained with hematoxylin and eosin, and/or fresh frozen is reported.